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Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma. | LitMetric

AI Article Synopsis

  • Cutaneous squamous cell carcinoma (SCC) is a common skin cancer that can spread and understanding its molecular changes can improve treatment and prevention strategies.
  • Researchers analyzed 40 skin tissue samples and found that 24% of SCC tumors had deletions related to the INPP5A gene on chromosome 10q.
  • Reduced levels of the INPP5A protein were frequently observed in both early and advanced stages of SCC, suggesting it might play a significant role in the cancer's development and progression.

Article Abstract

Cutaneous squamous cell carcinoma (SCC) occurs commonly and can metastasize. Identification of specific molecular aberrations and mechanisms underlying the development and progression of cutaneous SCC may lead to better prognostic and therapeutic approaches and more effective chemoprevention strategies. To identify genetic changes associated with early stages of cutaneous SCC development, we analyzed a series of 40 archived skin tissues ranging from normal skin to invasive SCC. Using high-resolution array-based comparative genomic hybridization, we identified deletions of a region on chromosome 10q harboring the INPP5A gene in 24% of examined SCC tumors. Subsequent validation by immunohistochemistry on an independent sample set of 71 SCC tissues showed reduced INPP5A protein levels in 72% of primary SCC tumors. Decrease in INPP5A protein levels seems to be an early event in SCC development, as it also is observed in 9 of 26 (35%) examined actinic keratoses, the earliest stage in SCC development. Importantly, further reduction of INPP5A levels is seen in a subset of SCC patients as the tumor progresses from primary to metastatic stage. The observed frequency and pattern of loss indicate that INPP5A, a negative regulator of inositol signaling, may play a role in development and progression of cutaneous SCC tumors.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955780PMC
http://dx.doi.org/10.1158/1940-6207.CAPR-10-0058DOI Listing

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