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A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells. | LitMetric
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A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells.

Yoshihiko Chiba Miki Tanabe Hiroyasu Sakai Shioko Kimura Miwa Misawa

Biochem Biophys Res Commun

Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

Published: October 2010

CPI-17 is a phosphorylation-dependent inhibitor of smooth muscle myosin light chain. Using yeast two-hybrid system, we have identified the receptor for activated C kinase 1 (RACK1) as a novel interaction partner of CPI-17. The direct interaction and co-localization of CPI-17 with RACK1 were confirmed by immunoprecipitation and confocal microscopy analysis, respectively. An in vitro assay system using recombinant/purified proteins revealed that the PKC-mediated phosphorylation of CPI-17 was augmented in the presence of RACK1. These results suggest that RACK1 may play a role in PKC/CPI-17 signaling pathway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486735PMC
http://dx.doi.org/10.1016/j.bbrc.2010.09.086DOI Listing

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