Few in the history of surgery and just as few in the history of medicine can reach the level of clinical visibility as achieved by the Mayo brothers. The brothers changed the face of medicine while they were alive, and their fame and influence continued to grow after their death in 1939. The Mayo American surgical legacy had incredible proportions. The brothers systematically modified the field as few others had done before. They were great surgical innovators who took the surgical techniques of others and added a touch of their own to make the surgical procedure better and more secure. The Mayos were the stars regionally, nationally, and around the world. They attracted attention from their generation and occupied center stage long after. To speak of the Mayos is to speak of the quintessential American values of professionalism, respect, commitment, and caring for their fellow human beings. Their creation, the Mayo Clinic, surpassed the wildest hopes and predictions that anyone could have had regarding their best dreams.
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Psychosocial Support Needs and Preferences Among Family Caregivers of ICU Patients with Severe Acute Brain Injury: A Qualitative Thematic Analysis.
Neurocrit Care
January 2025
Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Family caregivers of patients with severe acute brain injury (SABI) are at risk for clinically significant chronic emotional distress, including depression, anxiety, and posttraumatic stress. Existing psychosocial interventions for caregivers of intensive care unit (ICU) patients are not tailored to the unique needs of caregivers of patients with SABI, do not demonstrate long-term efficacy, and may increase caregiver burden. In this study, we explored the needs and preferences for psychosocial services among SABI caregivers to inform the development and adaptation of interventions to reduce their emotional distress during and after their relative's ICU admission.
View Article and Find Full Text PDFCreating a plasma coordination center to support COVID-19 outpatient trials across a national network of hospital blood banks.
J Clin Transl Sci
November 2024
Department of Neurology, BIOS Clinical Trial Coordinating Center, Trial Innovation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Introduction: In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods: A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Novel Variant in 2 Siblings With Sensorineural Hearing Loss and Cerebellar Ataxia.
Neurol Genet
December 2024
From the Department of Neurology (A.V., M.V.P., D.S.); Department of Clinical Genomics (L.A.S.); Division of Pediatric Pulmonology (N.D., R.P.B.), Department of Pediatrics and Adolescent Medicine; Division of Pediatric Rehabilitation Medicine, Department of Physical Medicine and Rehabilitation (A.E.R.); and Department of Pediatrics and Adolescent Medicine (C.R.F.), Mayo Clinic.
Article Synopsis
- The study focuses on a novel variant of the AIFM1 gene linked to early-onset hearing loss and progressive cerebellar ataxia in two siblings.
- Clinical evaluations included brain MRI scans, electromyography (EMG) studies, and whole genome sequencing (WGS), revealing various neurological symptoms and a unique genetic mutation.
- The findings suggest that AIFM1 variants should be considered in hereditary cases of cerebellar ataxia and auditory issues, contributing new insights into the genetic spectrum of related diseases.
Factors Influencing Nasoalveolar Molding Treatment Completion and Noncompletion in Infants with Cleft Lip and Palate.
Cleft Palate Craniofac J
November 2024
Department of Dental Specialties, Mayo Clinic, Rochester, MN, USA.
Objective: Identify sociodemographic factors and comorbidities predictive of nasoalveolar molding (NAM) treatment completion and noncompletion in infants with cleft lip with or without (+/-) cleft palate in a rural-suburban population.
Design: Retrospective cohort study.
Setting: Tertiary medical center.
World delirium awareness and quality survey in 2023-a worldwide point prevalence study.
Age Ageing
November 2024
Nursing Research, University Hospital Schleswig-Holstein, Kiel, Germany.
Background: Delirium, an acute brain dysfunction, is proposed to be highly prevalent in clinical care and shown to significantly increase the risk of mortality and dementia.
Objectives: To report on the global prevalence of clinically documented delirium and delirium-related clinical practices in wards caring for paediatric and adult patients in healthcare facilities.
Design: A prospective, cross-sectional, 39-question survey completed on World Delirium Awareness Day, 15 March 2023.
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