Objective: To analyze speciation and toxicity of arsenic in realgar bioleaching solution, and to explore its possible relation between speciation and toxicity.
Methods: Capillary zone electrophoresis (CZE) can be used quickly and simply onto the simultaneous separation and quantitative determination of the speciation of arsenic in realgar bioleaching solution. The effects of three different realgar bioleaching liquids on the acute toxicity level of rat were also investigated as well. Parallel experiments with traditional processing realgar via gastric irrigation were conducted for comparison.
Results: There are three different arsenic species in realgar bioleaching solution (iAs(III), iAs(V) MMA(V)), and the processing method largely affected speciation and toxicity of arsenic of it. It was found that the toxicity level was decreased through increasing the amount of MMA(V).
Conclusion: These results indicate that the species of arsenic may be tightly relationship to its toxicity in realgar bioleaching solution.
Download full-text PDF |
Source |
---|
Pak J Pharm Sci
May 2019
Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou, Gansu, PR China / School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Realgar as a kind of arsenic agent is currently used to treat APL in China. The effectiveness and low toxicity of realgar have been verified, lower than arsenic trioxide. Although the therapeutic efficacy of realgar is blocked severely by its poor insolubility in water.
View Article and Find Full Text PDFArch Pharm Res
August 2019
School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou, 730020, China.
PML/retinoic acid receptor alpha (RARα), as a hallmark of acute promyeloid leukemia (APL), is directly related to the outcome of clinical APL remedy. It is reported that arsenicals can effectively degrade PML/RARα, such as arsenic trioxide and realgar. However, the high toxicity or insolubility have hampered their clinical applications.
View Article and Find Full Text PDFBiol Res
May 2017
School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou, 730020, People's Republic of China.
Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (AsS). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A.
View Article and Find Full Text PDFAsian Pac J Cancer Prev
January 2015
Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Science, Lanzhou University, Lanzhou, China E-mail :
Arch Pharm Res
March 2014
Institute of Microbiology and Biochemical Pharmacy, School of Pharmaceutics, Lanzhou University, Lanzhou, People's Republic of China,
Although realgar bioleaching solution (RBS) has been proved to be a potential candidate for cancer therapy, the mechanisms of RBS anticancer are still far from being completely understood. Dosed with RBS in C. elegans, the multivulva phenotype resulting from oncogenic ras gain-of-function was inhibited in a dose dependent manner.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!