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Toward a More General Consent for the Use of Patients' Biological Material and Health Information for Medical Research-The Patient Perspective.
Biopreserv Biobank
January 2025
Department for Food Safety, Norwegian Institute of Public Health, Oslo, Norway.
Biological material and health information from patients are valuable for medical research. Under a "broad" consent model, hospital patients in Norway can consent to their biological material and health information being stored in research biobanks and used for "specific, broadly defined research purposes" within a specified medical research area but not for medical research in general. Patients are asked to provide new consent each time researchers wish to use their material in a different medical research area.
View Article and Find Full Text PDFDelivering family centred services in child-onset disability: a mixed methods approach to understanding health professionals' experiences and approaches.
Disabil Rehabil
January 2025
Department of Pediatrics, University of Melbourne, Melbourne, Australia.
Aim: Family-centred service aims to build family capacity to support their children, but behaviours supporting capacity-building vary. We explored what influences the way service providers think about and approach family-centred service.
Method: An online survey drew on experiences, beliefs, and perspectives of Australian providers.
Movi: A fast and cache-efficient full-text pangenome index.
iScience
December 2024
Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, US.
Pangenome indexes are promising tools for many applications, including classification of nanopore sequencing reads. Move structure is a compressed-index data structure based on the Burrows-Wheeler Transform (BWT). It offers simultaneous O(1)-time queries and O(r) space, where r is the number of BWT runs (consecutive sequence of identical characters).
View Article and Find Full Text PDFEtomidate and its derivatives: time to say goodbye?
Br J Anaesth
January 2025
Universitätsmedizin Göttingen, Göttingen, Germany.
Etomidate, an intravenous hypnotic used for anaesthesia and critical care, is known for its undesirable side effects, including pain on injection, myoclonus, and adrenocortical depression. Despite its continued clinical use because of its haemodynamic stability and rapid onset and offset of effect, alternatives like propofol, ketamine, and remimazolam offer fewer drawbacks. Recent efforts to improve etomidate through chemical modifications, such as methoxyethyl etomidate hydrochloride (ET-26), have shown limited success, with persistent issues like involuntary muscle movements and adrenocortical suppression.
View Article and Find Full Text PDFEnabling simultaneous photoluminescence spectroscopy and X-ray footprinting mass spectrometry to study protein conformation and interactions.
Anal Methods
January 2025
Molecular Foundry Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
X-ray footprinting mass spectrometry (XFMS) is a structural biology method that uses broadband X-rays for hydroxyl radical labeling to map protein interactions and conformation in solution. However, while XFMS alone provides important structural information on biomolecules, as we move into the era of the interactome, hybrid methods are becoming increasingly necessary to gain a comprehensive understanding of protein complexes and interactions. Toward this end, we report the development of the first synergetic application of inline and real-time fluorescent spectroscopy at the Advanced Light Source's XFMS facility to study local protein interactions and global conformational changes simultaneously.
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