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Aging Skin: A Dermatitis To Which All Flesh Is Heir?
J Cutan Pathol
January 2025
Program in Dermatopathology, Department of Pathology, Brigham and Women's Hospital/Mass General Brigham, Boston, Massachusetts, USA.
The human body is composed mostly of water fortified by a variety of proteins, fats, carbohydrates, vitamins, minerals, and other nutrients, all organized into an elegant structurally complex and functionally efficient machine in which our consciousness resides. This heterogeneous assemblage of essential ingredients is enclosed in a container known as the integument, or simply, the skin. The container is as important as its contents; when itself devoid of structural and functional integrity, it will both leak as well as become infused with potentially harmful external agents.
View Article and Find Full Text PDFSolving the maximum cut problem using Harris Hawk Optimization algorithm.
PLoS One
January 2025
Computer Science and Engineering Discipline, Khulna University, Khulna, Bangladesh.
The objective of the max-cut problem is to cut any graph in such a way that the total weight of the edges that are cut off is maximum in both subsets of vertices that are divided due to the cut of the edges. Although it is an elementary graph partitioning problem, it is one of the most challenging combinatorial optimization-based problems, and tons of application areas make this problem highly admissible. Due to its admissibility, the problem is solved using the Harris Hawk Optimization algorithm (HHO).
View Article and Find Full Text PDFOrchard: Building large cancer phylogenies using stochastic combinatorial search.
PLoS Comput Biol
December 2024
Computational and Systems Biology Program, Sloan Kettering Institute, New York, New York, United States of America.
Phylogenies depicting the evolutionary history of genetically heterogeneous subpopulations of cells from the same cancer, i.e., cancer phylogenies, offer valuable insights about cancer development and guide treatment strategies.
View Article and Find Full Text PDFEpistatic hotspots organize antibody fitness landscape and boost evolvability.
Proc Natl Acad Sci U S A
January 2025
Department of Physics and Astronomy, University of California, Los Angeles, CA 90095.
The course of evolution is strongly shaped by interaction between mutations. Such epistasis can yield rugged sequence-function maps and constrain the availability of adaptive paths. While theoretical intuition is often built on global statistics of large, homogeneous model landscapes, mutagenesis measurements necessarily probe a limited neighborhood of a reference genotype.
View Article and Find Full Text PDFEnhancement of the Thermostability of Esterase by Combinatorial Rational Design.
Molecules
December 2024
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
The esterase EstSIT01 from can catalyze the asymmetric hydrolysis of -dimethyl ester to produce the crucial chiral intermediate (4, 5)-hemimethyl ester for -biotin synthesis. Despite its high yields and stereoselectivity, the low thermostability of EstSIT01 limits its practical application. Herein, two kinds of rational strategies were combined to enhance the thermostability of EstSIT01.
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