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Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence. | LitMetric
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Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence.

Anass Znabet Job Zonneveld Elwin Janssen Frans J J De Kanter Madeleine Helliwell Nicholas J Turner Eelco Ruijter Romano V A Orru

Chem Commun (Camb)

Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.

Published: November 2010

We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds.

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 Source
http://dx.doi.org/10.1039/c0cc02938fDOI Listing

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