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| http://dx.doi.org/10.1136/ard.2010.134155 | DOI Listing |
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Intervertebral disc degenerative disease in South Africa: a case-control analysis of selected gene variants.
Mol Biol Rep
September 2024
Precision Medicine Unit, Department of Biotechnology, University of the Western Cape, Cape Town, South Africa.
Background: Intervertebral disc (IVD) degenerative disease is a multifactorial disease for which genetics plays an integral role. Several genes, and their variants, associated with the development and progression of IVD degenerative disease have been identified. While several studies have investigated these genes in Asian and European populations, no available evidence exists for the South African population.
View Article and Find Full Text PDFDecisive gene strategy on osteoarthritis: a comprehensive whole-literature based approach for conclusive gene targets.
Aging (Albany NY)
September 2024
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114201, Taiwan, R.O.C.
Background: Previous meta-analyses only examined the association between single or several gene polymorphisms and osteoarthritis (OA), whereas no studies have concluded that there are existing all gene loci that associate with OA.
Objective: To assess whether a definite conclusion of the association between the gene loci and OA can be drawn.
Methods: Decisive gene strategy (DGS), a literature-based approach, was used to search PubMed, Embase, and Cochrane databases for all meta-analyses that associated gene polymorphisms and OA.
The Association of Vitamin D, Growth/Differentiation Factor 5 (GDF-5) Gene Polymorphism, and Serum GDF-5 Protein in Obese Patients With Knee Osteoarthritis.
Cureus
November 2023
Health Affairs, Ministry of Health, Taif, SAU.
Background and objective Osteoarthritis (OA) is influenced by genetics and environmental factors, including vitamin D deficiency. This study aimed to investigate the association between vitamin D levels, growth/differentiation factor 5 (GDF-5) gene polymorphism, and serum GDF-5 in obese females with knee OA (KOA) in Saudi Arabia. Methodology The study enrolled 60 female patients with OA and 60 healthy females as controls.
View Article and Find Full Text PDFThe association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis.
J Orthop Surg Res
October 2023
Department of Orthopaedics, Beijing Friendship Hospital Pinggu Campus, Capital Medical University, Beijing, 101200, China.
Background: Osteoarthritis (OA) is caused by a complex set of pathophysiological factors. The genetic factors involved in the occurrence and progress of the disease have been widely discussed by scholars. It was found that growth differentiation factor 5 (GDF5) gene polymorphisms may be linked to OA susceptibility, which has been controversial and needs to be further confirmed by an updated meta-analysis.
View Article and Find Full Text PDFAre commercial genetic injury tests premature?
Scand J Med Sci Sports
September 2023
Health through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Division of Physiological Sciences, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Introduction: Several direct-to-consumer (DTC) genetic testing companies have emerged that claim to be able to test for susceptibility for musculoskeletal injuries. Although there are several publications on the emergence of this industry, none have critically evaluated the evidence for the use of genetic polymorphisms in commercial tests. The aim of this review was to identify, where possible, the polymorphisms and to evaluate the current scientific evidence for their inclusion.
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