A 48 year old postmenopausal female noted hyperpigmentation of the left areola 3 months after beginning estradiol spray to her left forearm. She then applied the spray to the right forearm instead until the areolae were the same color again and then applied 1 spray to each forearm thereafter.

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http://dx.doi.org/10.1016/j.ajog.2010.08.010DOI Listing

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