AI Article Synopsis
- The study aimed to assess how calcium folinate (CF) can protect against damage caused by methotrexate (MTX) in rat endosalpinx.
- The results showed that both low- and high-dose MTX led to endosalpingitis and altered steroid receptor expression, but these effects were either completely or partially reversed when CF was used alongside MTX.
- This suggests that CF can help mitigate the harmful side effects of MTX treatment.
Article Abstract
The aim of this study was to evaluate the protective effect of calcium folinate (CF) applied in 10% of the methotrexate (MTX) dosage against morphologic and steroid-receptor damage induced by MTX in rat endosalpinx. The result indicated that endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low- and high-dose MTX in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX.
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| http://dx.doi.org/10.1016/j.fertnstert.2010.08.028 | DOI Listing |
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