AI Article Synopsis
- Progressive mucinous histiocytosis (PMH) is a rare skin condition that doesn't really cause serious problems but can be tricky to diagnose.
- Doctors now usually use modern tools like immunohistochemistry to diagnose skin issues, but sometimes they still need to use older tools like electron microscopy.
- In this case, a 60-year-old woman had unusual skin bumps, and only the electron microscopy helped doctors correctly identify PMH when other tests didn't work.
Article Abstract
Background: Progressive mucinous histiocytosis (PMH) is a benign, non-Langerhans cell histiocytosis with characteristic ultrastructural features that can be used for diagnosis. Once an important tool in dermatologic diagnosis, electron microscopy has been largely replaced by immunohistochemistry and immunofluorescence techniques today. However, electron microscopy occasionally still plays a crucial role in the diagnosis of dermatologic conditions. We report a case of PMH as an example of a dermatologic disorder that requires electron microscopy for its diagnosis.
Methods: A 60-year-old woman presented to our clinic with a history of small, sharply demarcated, skin-colored papules ranging from 2 to 5 mm in diameter distributed over the arms, forearms, and dorsal hands. The results of light microscopy, immunohistochemical studies, and clinical examination were inconclusive. Another biopsy for electron microscopy showed the characteristic features of PMH.
Conclusion: This case demonstrates that a dermatopathology service still needs to have access to electron microscopy for diagnostic purposes to successfully diagnose a small number of rare conditions.
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| http://dx.doi.org/10.2310/7750.2010.09047 | DOI Listing |
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