Two-photon excitation of a single-photon forbidden Auger resonance has been observed and investigated using the intense extreme ultraviolet radiation from the free electron laser in Hamburg. At the wavelength 26.9 nm (46 eV) two photons promoted a 3d core electron to the outer 4d shell. The subsequent Auger decay, as well as several nonlinear above threshold ionization processes, were studied by electron spectroscopy. The experimental data are in excellent agreement with theoretical predictions and analysis of the underlying multiphoton processes.
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http://dx.doi.org/10.1103/PhysRevLett.104.213001 | DOI Listing |
Alzheimers Dement
December 2024
New York University Grossman School of Medicine, New York, NY, USA.
Background: Abnormal neuronal activity was observed in awake and behaving tauopathy mice using two-photon calcium imaging. Our previous study has revealed the relationship between tau pathology and altered neuronal calcium dynamics within the motor cortex of JNPL3 tauopathy mice at different stages of disease progression, specifically at 6 and 12 months of age (Wu Q et al, Neurobiol. Dis.
View Article and Find Full Text PDFAnal Chem
January 2025
School of Chemical and Environmental Engineering, Anhui Polytechnic University, 241000 Wuhu, P.R. China.
At present, some progress has been made in developing NIR light-responsive free radical generators. However, the efficacy of theranostics continues to be hindered by tumor-associated inflammatory reactions. Hence, fulfilling the in situ release of free radicals upon NIR light excitation specifically activated by the inflammation microenvironment would be an ideal strategy for efficient inflammation eradication and tumor suppression but remains a challenge.
View Article and Find Full Text PDFBiosensors (Basel)
December 2024
Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka.
Bright biocompatible fluorescent imaging dyes with red to near-infrared (NIR) emissions are ideal candidates for fluorescence microscopy applications. Pyrene-benzothiazolium hemicyanine dyes are a new class of lysosome-specific probes reported on recently. In this work, we conduct a detailed implementation study for a pyrene-benzothiazolium derivative, BTP, to explore its potential imaging applications in fluorescence microscopy.
View Article and Find Full Text PDFAdv Mater
December 2024
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHK-Shenzhen), Shenzhen, Guangdong, 518172, P. R. China.
The existence of residual small-size tumors after surgery is a major factor contributing to the high recurrence rate of glioblastoma (GBM). Conventional adjuvant therapeutics involving both chemotherapy and radiotherapy usually exhibit unsatisfactory efficacy and severe side effects. Recently, two-photon photodynamic therapy (TP-PDT), especially excited by the second near-infrared (NIR-II) light, offers an unprecedented opportunity to address this challenge, attributed to its combinational merits of PDT and TP excitation.
View Article and Find Full Text PDFChem Sci
December 2024
Institute of Advanced Materials, Wroclaw University of Science and Technology Wrocław Poland
Near-infrared (NIR) emitters with high two-photon absorption (2PA) cross-sections are of interest to enable imaging in the tissue transparency windows. This study explores the potential of DNA-stabilized silver nanoclusters (Ag -DNAs) as water-soluble two-photon absorbers. We investigate 2PA of four different atomically precise Ag -DNA species with far-red to NIR emission and varying nanocluster and ligand compositions.
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