We report a new bioorthogonal ligation reaction between p-nitrodiphenylazirine and dimethyl fumarate. This photoinduced azirine-alkene cycloaddition provides a rapid (~2 min) and highly selective route to protein conjugation at neutral pH and room temperature in biological medium.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964347 | PMC |
| http://dx.doi.org/10.1039/c0cc02863k | DOI Listing |
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