Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965585 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2010.08.058 | DOI Listing |
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