AI Article Synopsis
- A fluorescent nucleobase analog called 7-aminoquinazoline-2,4-(1H,3H)-dione is designed for use in DNA oligonucleotides.
- This analog can detect mismatches in DNA pairing, specifically identifying when guanine (G) is incorrectly paired.
- When a mismatch occurs, the analog shows an increase in fluorescence, making it a useful tool for analyzing DNA pairings.
Article Abstract
A fluorescent nucleobase analogue, 7-aminoquinazoline-2,4-(1H,3H)-dione, is incorporated into a DNA oligonucleotide and senses mismatched pairing by displaying G-specific fluorescence enhancement.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032630 | PMC |
| http://dx.doi.org/10.1039/c0ob00413h | DOI Listing |
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