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http://dx.doi.org/10.1001/jama.2010.1343 | DOI Listing |
BDNF plays a crucial role in shaping the structure and function of neurons. BDNF signaling in the dorsolateral striatum (DLS) is part of an endogenous pathway that protects against the development of alcohol use disorder (AUD). Dysregulation of BDNF levels in the cortex or dysfunction of BDNF/TrkB signaling in the DLS results in the escalation of alcohol drinking and compulsive alcohol use.
View Article and Find Full Text PDFMental Health Sci
September 2024
Department of Psychiatry, UC San Diego, La Jolla, CA, USA.
Background: The influence of alcohol use on later neurocognitive functioning is well researched, yet few studies have investigated whether neurocognition post-drinking initiation in adolescence predicts changes in later alcohol use.
Objective: Investigate neurocognitive task performance during maximum alcohol use in late adolescence as predictors of drinking behaviors 3-7 years later.
Methods: Analyses () were conducted on a longitudinal dataset involving adolescents (12-13 years-old) who were followed for 16 years.
Public Health
January 2025
Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de León, 24071, León, Spain; The Research Group in Gene-Environment and Health Interactions (GIIGAS), Institute of Biomedicine (IBIOMED), Universidad de León, 24071, León, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), 28029, Madrid, Spain.
Objectives: The COVID-19 pandemic caused unprecedented restrictions, leading to differences in the frequency and patterns of alcohol consumption, especially among young adults. This systematic review aims to investigate the overall evidence concerning changes in alcohol consumption in this period.
Study Design: Systematic review.
Digit Health
January 2025
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Background: Advancing evidence-based, tailored interventions for substance use disorders (SUDs) requires understanding temporal directionality while upholding ecological validity. Previous studies identified loneliness and craving as pivotal factors associated with alcohol consumption, yet the precise directionality of these relationships remains ambiguous.
Objective: This study aims to establish a smartphone-based real-life intervention platform that integrates momentary assessment and intervention into everyday life.
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