AI Article Synopsis
- The study examines the pathophysiology of peritoneal ultrafiltration and uses the peritoneal equilibration test to understand why some patients struggle to maintain ultrafiltration rates during peritoneal dialysis.
- Common causes for ultrafiltration loss include membrane failure, reduced blood flow in the peritoneum, excessive fluid reabsorption, catheter issues, and fluid retention.
- Strategies for addressing ultrafiltration loss include using medication to improve membrane function, fixing mechanical problems, reducing peritonitis rates, and carefully managing glucose levels and dwell times in the dialysis process.
Article Abstract
Pathophysiology of peritoneal ultrafiltration is analyzed in the present study. Peritoneal equilibration test is the easiest procedure to study in detail the possible causes of failure to control the ultrafiltration rate in patients undergoing peritoneal dialysis. Membrane failure, reduction in peritoneal blood flow, excessive lymphatic reabsorption catheter malposition, and fluid sequestration are the most common causes of ultrafiltration loss. Pharmacologic manipulation of peritoneal membrane, correction of mechanical inconvenients, reduction in peritonitis rate and in the level of immunostimulation of the mesothelial macrophages, together with a careful policy in terms of glucose concentration in the dialysate and dwell times may contribute not only to treat different forms of ultrafiltration loss but also to prevent their incidence.
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