Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jm100888d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer's disease.
Mol Neurodegener
January 2025
Center for Cognition and Sociality, Life Science Institute (LSI), Institute for Basic Science (IBS), Daejeon, Republic of Korea.
Background: Alzheimer's Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic GABA and HO are associated with memory impairment in AD and synthesized through the Monoamine Oxidase B (MAOB)-mediated multi-step degradation of putrescine. However, the enzymes downstream to MAOB in this pathway remain unidentified.
View Article and Find Full Text PDFTheoretical Study of Antioxidant and Prooxidant Potency of Protocatechuic Aldehyde.
Int J Mol Sci
January 2025
Institute for Information Technologies Kragujevac, Department of Science, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.
In this study, the antioxidant and prooxidant potency of protocatechuic aldehyde (PCA) was evaluated using density functional theory (DFT). The potency of direct scavenging of hydroperoxyl (HOO) and lipid peroxyl radicals (modeled by vinyl peroxyl, HC=CHOO) involved in lipid peroxidation was estimated. The repair of oxidative damage in biomolecules (lipids, proteins and nucleic acids) and the prooxidant ability of PCA phenoxyl radicals were considered.
View Article and Find Full Text PDFPotential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular Disease.
Antioxidants (Basel)
November 2024
Barts & The London Faculty of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
The majority of naturally occurring mutations of the human gene , are associated with reduced or completely absent xanthine oxidoreductase (XOR) activity, leading to a disease known as classical xanthinuria, which is due to the accumulation and excretion of xanthine in urine. Three types of classical xanthinuria have been identified: type I, characterised by XOR deficiency, type II, caused by XOR and aldehyde oxidase (AO) deficiency, and type III due to XOR, AO, and sulphite oxidase (SO) deficiency. Type I and II are considered rare autosomal recessive disorders, a condition where two copies of the mutated gene must be present to develop the disease or trait.
View Article and Find Full Text PDFElucidating the Phase I metabolism of psilocin in vitro.
Arch Toxicol
January 2025
Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.
Psilocin is a well-studied controlled substance with potential psychotherapeutic applications. However, research gaps remain regarding its metabolism. Our objective was to elucidate a comprehensive Phase I metabolic profile of psilocin to support its forensic management and clinical development.
View Article and Find Full Text PDF"Elegy of blossoms": Decrypting the dynamics of petal senescence in L.
Physiol Mol Biol Plants
December 2024
Department of Botany, University of Kashmir, Srinagar, 190006 India.
Petal senescence represents a crucial phase in the developmental continuum of flowers, ensuing tissue differentiation and petal maturation, yet anteceding seed formation and development. Instigation of petal senescence entails myriad of changes at the cytological, physiological and molecular dimensions, mirroring the quintessential characteristics of cell death. In the current investigation biochemical and molecular intricacies were scrutinized across various developmental stages (bud to the senescent phase).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!