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Cell wall anchoring of the 37-kilodalton oncofetal antigen by Lactobacillus plantarum for mucosal cancer vaccine delivery. | LitMetric
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Cell wall anchoring of the 37-kilodalton oncofetal antigen by Lactobacillus plantarum for mucosal cancer vaccine delivery.

Lasse Fredriksen Geir Mathiesen Mouldy Sioud Vincent G H Eijsink

Appl Environ Microbiol

Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, N-1432 Ås, Norway.

Published: November 2010

The 37-kDa oncofetal antigen (OFA), a tumor immunogen expressed on all mammalian cancers examined to date, was secreted and anchored to the cell wall of Lactobacillus plantarum using homologous signal peptides and LPxTG anchors. Orally administered L. plantarum expressing anchored OFA induced a specific immune response against OFA in mice.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976233PMC
http://dx.doi.org/10.1128/AEM.01031-10DOI Listing

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