Biliary hamartomas or von-Meyenburg complexes form part of a spectrum of ductal plate malformation that includes polycystic liver disease, congenital hepatic fibrosis, and Caroli disease. These lesions are known to have neoplastic transformation. Development of intrahepatic cholangiocarcinoma is well described in these complexes. Rarely, hepatocellular carcinomas (HCCs) have been seen in association with bile duct hamartomas, however; it is not clear whether development of HCC is an epiphenomenon unrelated to the precursor lesion or biliary hamartomas may progress to liver cancers. We herein report 4 interesting cases of hepatitis C virus-, alcohol-, and nonalcoholic fatty liver disease-associated end-stage liver disease with coexisting HCC and multiple large von-Meyenburg complexes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.anndiagpath.2010.04.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pictorial Review of Rare Pancreatic Tumors and Tumor-like Lesions: Radiologic-Pathologic Correlation.
Medicina (Kaunas)
October 2024
Medical Science Research Institute, Kyung Hee University Hospital, Seoul 02447, Republic of Korea.
Rare pancreatic tumors and non-neoplastic tumor-like lesions present a diagnostic challenge due to their uncommon occurrence and overlapping imaging characteristics with more prevalent pancreatic neoplasms. Advances in imaging technologies and diagnostic criteria have contributed to increased detection of these rare entities in clinical practice. This pictorial review focuses on the radiologic-pathologic correlation of rare pancreatic tumors, including colloid carcinoma, acinar cell carcinoma, pancreatoblastoma, primary pancreatic lymphoma, and non-neoplastic tumor-like lesions such as hamartomas and inflammatory pseudotumors.
View Article and Find Full Text PDFVon-Meyenburg Complex: A Case of Elevated Gamma-GT.
Cureus
October 2024
Internal Medicine, Unidade Local de Saúde do Alto Minho, Viana do Castelo, PRT.
Article Synopsis
- The Von-Meyenburg complex, or biliary hamartomas, are benign growths of the bile ducts inside the liver, usually found by accident and often symptom-free.
- They can appear like cancerous lesions on imaging tests, but they typically have little importance regarding disease progression.
- There may be a genetic link in some families, particularly related to the PKHD1 gene, which is often associated with polycystic kidney and liver disease.
Ductal hamartoma of the pancreas: A clinicopathologic study.
Hum Pathol
November 2024
Yale University School of Medicine, Department of Pathology, New Haven, CT, USA. Electronic address:
Article Synopsis
- Benign ductular proliferative lesions resembling hepatic von-Meyenburg Complexes have been identified in the pancreas, termed pancreatic ductal hamartomas (PDH), but their characteristics and causes are still unclear.
- A study reviewed three cases of PDH found during evaluations for other pancreatic conditions, often misdiagnosed as intra-ductal pancreatic mucinous cystic neoplasms, leading to surgical removal.
- PDH were found incidentally in 4.5% of pancreatic resections, showing varied sizes and histological features, but their connection to pancreatic cancer or IPMN remains uncertain.
A rare encounter - Unveiling the mysteries of biliary hamartoma: A case report.
Int J Surg Case Rep
September 2024
Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Introduction: Biliary hamartomas are rare congenital development anomaly of bile ducts, which are detected incidentally. They often present as multiple lesions on liver surface which resembles metastatic lesions. We report a case of acute calculous cholecystitis ultimately diagnosed to have asymptomatic multiple biliary hamartomas.
View Article and Find Full Text PDFHepatic vascular hamartoma in a cat: a case report with literature review.
Front Vet Sci
June 2024
Department of Anatomic Pathology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
Vascular hamartomas represent a focal proliferation of disorganized vascular tissue, which is usually present at birth. An 8-month-old Scottish fold female cat presented with abdominal distention, mild dyspnea, pale mucous membranes, and lethargy. Ultrasound examination revealed a hepatic mass resembling multiple cysts affecting the right medial lobe.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!