Cells possess internal ∼24 hr or circadian clocks that synchronize physiological processes with daily cycles of light and nutrient availability. In this issue, Asher et al. (2010) find that PARP-1 (poly(ADP-ribose) polymerase 1) modifies components of the clock machinery in response to feeding, providing a mechanism for how metabolic rhythms coordinate with circadian rhythms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694762 | PMC |
| http://dx.doi.org/10.1016/j.cell.2010.08.037 | DOI Listing |
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