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The effects of bone marrow derived myelopeptide-1 (MP-1) on functional activities of normal murine phagocytes and phagocytes obtained from mice treated with cytostatic agent cyclophosphan (CY) were studied in vivo and in vitro. We demonstrated immunocorrecting effect of MP-1 on functional activity of bone marrow and peripheral blood phagocytes. An optimal protocol of MP-1 injections during cytostatic therapy was developed to obtain maximal efficacy in immunocorrection.
View Article and Find Full Text PDFThe objective of the present study was to determine the absolute and relative numbers of T-lymphocytes, B-lymphocytes, T-suppressors, T-helpers, phagocytes, immunoglobulins A, M, and G in blood sera of patients presenting with chronic suppurative otitis media who had undergone sanation surgery. The study included tests for the evaluation of immunological efficiency of combined treatment with imunofan and myelopid in 89 patients divided into two groups. Pretreatment immunological status of all patients was characterized by reduced B-lymphocyte, T-helper, and phagocyte counts coupled to the elevated levels of IgM and T-suppressors.
View Article and Find Full Text PDF[Protective efficacy of combined administration of the multicomponent vaccine and the immunomodulator myelopid in experimental infections in mice].
Zh Mikrobiol Epidemiol Immunobiol
August 2001
Research Institute of Immunology, Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
The influence of myelopid (MP) on the protective activity of polycomponent vaccine VP-4 prepared from the antigens of opportunistic bacteria was studied on experimental infections of mice, caused by Klebsiella pneumoniae, Salmonella typhimurium and Staphylococcus aureus. In staphylococcal and Klebsiella infections the joint administration of vaccine VP-4 and MP produced more pronounced protective effect than each of these preparations, introduced alone. The protective action of vaccine VP-4 was specially enforced by MP in cases of local staphylococcal infection.
View Article and Find Full Text PDFEffects were studied of immunomodulation on the clinical and immunological status of patients with acute pyelonephritis, 4 groups of patients were identified: those treated with T- and B-activin (myelopide); intravascular irradiation with Helium-Neon laser; antibiotics only (control group). All immunotherapeutic alternatives were found to be effective in the treatment of acute pyelonephritis. Apparent T-activin and myelopeptide immunostimulating actions appear to account for their high clinical efficacy.
View Article and Find Full Text PDF[The efficacy of combined immunocorrection in patients undergoing a treatment for chronic epitympanitis].
Vestn Otorinolaringol
January 1998
Kafedra LOR-bolezneĭ RMAPO, Voronezhskaia oblastnaia klinicheskaia bol'nitsa.
Ninety six patients with chronic epitympanitis treated surgically were examined immunologically and allocated in 4 groups. Suppressed T- and B-cell immunities were found. Patients of group 1 received antibiotics and antihistamine drugs (controls), patients of group 2, 3 and 4 were given in addition timontin, myelopid and timontin + myelopid, respectively.
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