Effect of memantine in Alzheimer's disease evaluated by visual-evoked potentials to pattern-reversal, motion-onset, and cognitive stimuli.

J Clin Neurophysiol

Department of Pathophysiology-Electrophysiological Laboratory, Charles University, Faculty of Medicine in Hradec Králové, Czech Republic.

Published: October 2010

The authors tested visual-evoked potentials to pattern-reversal, motion-onset, and visual cognitive event-related potentials in 17 patients with mild-to-moderate Alzheimer's disease treated with Memantine (noncompetitive N-methyl-D-aspartic acid antagonist) to verify whether these objective methods can evaluate its therapeutic effect. The patients were examined before Memantine administration and after 3 and 6 months from the treatment onset. Besides electrophysiology, psychologic Alzheimer Disease Assessment Scale-cognitive part (ADAS-cog) test was also performed. Neither ADAS-cog nor any of the electrophysiological tests were able to prove a significant beneficial effect of Memantine therapy in our group of patients. The results of psychologic and electrophysiological tests did not correlate. An individual improvement of ADAS-cog score (decrease of score by 4 and more points) was present in only 29% of patients, improvement of event-related potentials (shortening of P300 peak latency by at least 20 milliseconds) occurred in 42% of patients. Conversely, in 52% of patients, Memantine therapy led to transitory decline of motion processing (delay of N2 peak latency of the motion-onset visual-evoked potentials by at least 10 milliseconds after the first 3 months of therapy, followed by return to pretherapy values in next 3 months).

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNP.0b013e3181f413cbDOI Listing

Publication Analysis

Top Keywords

visual-evoked potentials
12
alzheimer's disease
8
potentials pattern-reversal
8
pattern-reversal motion-onset
8
event-related potentials
8
electrophysiological tests
8
memantine therapy
8
peak latency
8
patients
6
memantine
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!