AI Article Synopsis
- Hantaviruses are emerging category A pathogens from the Bunyaviridae family that have a unique way of starting translation of their mRNAs.
- The viral nucleocapsid protein (N) binds to the 5' m7G cap of the mRNA and the 40S ribosomal subunit to initiate this process.
- The study reveals that N interacts specifically with ribosomal protein S19 (RPS19), which helps ribosome loading on capped mRNAs for translation initiation.
Article Abstract
Hantaviruses, members of the Bunyaviridae family, are emerging category A pathogens that initiate the translation of their capped mRNAs by a novel mechanism mediated by viral nucleocapsid protein (N). N specifically binds to the mRNA 5' m7G cap and 40S ribosomal subunit, a complex of 18S rRNA and multiple ribosomal proteins. Here, we show that N specifically interacts with the ribosomal protein S19 (RPS19), located at the head region of the 40S subunit. We suggest that this N-RPS19 interaction facilitates ribosome loading on capped mRNAs during N-mediated translation initiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976419 | PMC |
| http://dx.doi.org/10.1128/JVI.01388-10 | DOI Listing |
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