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Article Synopsis
  • Localized bladder amyloidosis is a rare condition that can be mistaken for a bladder tumor, with only over 200 cases documented.
  • A 67-year-old woman experienced painless blood in urine, leading to tests that suggested bladder amyloidosis, including a Congo red staining potentially indicating the presence of amyloid.
  • The excised tissue from her procedure showed unexpected pink-staining patterns but did not confirm amyloidosis through Congo red staining, highlighting the importance of thorough evaluation for diagnosis despite negative results.
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Aims: Wild-type transthyretin cardiac amyloidosis (ATTRwt CA) is a common, underdiagnosed cause of heart failure (HF) in the elderly. Concurrent extracardiac amyloid infiltration might be responsible for a specific frailty phenotype. This study aims to compare the prevalence and characteristics of frailty parameters in HF patients, with or without ATTRwt CA.

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An 85-year-old woman visited our hospital with a complaint of asymptomatic gross hematuria. Cystoscopy showed a non-papillary sessile tumor about 3 cm in size. Magnetic resonance imaging (MRI) suggested invasion of surrounding fat tissue.

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Context.—: Localized amyloidosis of the bladder is rare and often mimics bladder malignancy. It is typically associated with the extracellular deposition of monoclonal light chains, either κ or λ.

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Article Synopsis
  • A case study discusses a rare instance of amyloid A amyloidosis in the bladder following treatment for bladder cancer in an 87-year-old man.
  • The patient experienced recurrent bladder tumors, with biopsy results indicating the presence of amyloid A, which might be linked to his existing cardiac issues.
  • The findings suggest that bladder tumor pathology can help identify systemic amyloid A amyloidosis, potentially explaining the patient's cardiac complications.
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