Sporulation of the budding yeast Saccharomyces cerevisiae — equivalent to gametogenesis in higher organisms, is a complex differentiation program induced by starvation of cells for nitrogen and carbon. Such environmental conditions activate coordinated, sequential changes in gene expression leading to production of haploid, stress-resistant spores. Sporulation comprises two rounds of meiosis coupled with spore morphogenesis and is tightly controlled to ensure viable progeny. This review concerns the regulation of differentiation process by nutritional and transcriptional signals.
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Effect of halo-tolerance gene Hal5 on ethanol tolerance of .
BBA Adv
October 2024
Department of Biochemistry, Panjab University, Chandigarh 160014, India.
Hal5 gene is involved in halo-tolerance of during high salt stress. Ethanol stress and high salt stress have similarities, as both decrease the availability of water for cells and strain the osmotic homeostasis across the cell membrane. The Hal5 over-expression strain of yeast has more ethanol tolerance, but the Hal5 null mutant strain also has more ethanol tolerance than the wild-type strain.
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Facultad de Química y Biología, Departamento de Biología, Universidad de Santiago de Chile, Santiago, 9170022, Chile.
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View Article and Find Full Text PDFNonsense-mediated decay (NMD) is a eukaryotic surveillance pathway that controls degradation of cytoplasmic transcripts with aberrant features. NMD-controlled RNA degradation acts to regulate a large fraction of the mRNA population. It has been implicated in cellular responses to infections and environmental stress, as well as in deregulation of tumor-promoting genes.
View Article and Find Full Text PDFThe yeast checkpoint kinase Dun1p represses transcription of RNR genes independently of catalytic activity or Rad53p during respiratory growth.
J Biol Chem
January 2025
Department of Biological Sciences, St. John's University, Queens, New York, USA. Electronic address:
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mBio
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Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
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