Aims: Alcohol tolerance is a hallmark indicator of alcohol dependence. Even so, the allure of peers' admiration for having the ability to drink heavily may lead some adolescents and young adults to practice, or 'train', to increase their tolerance (particularly at US colleges, where heavy drinking is highly prevalent and central to the social culture). This is a potential health hazard that has not been documented empirically. Thus, we initiated a study of tolerance 'training' and its association to risky and heavy drinking.
Design, Setting And Participants: A cross-sectional online survey of 990 college student life-time drinkers at a large Midwestern US university.
Findings: Of the sample, 9.9% (n = 97) reported deliberately 'training' to increase tolerance. On average, they reported increasing from approximately seven to 10 US standard drinks in a night prior to 'training' to 12-15 drinks at the end of 'training,' over approximately 2-3 weeks' duration. Although the proportion of frequent binge drinking among 'non-trainers' (34.4%) was similar to national rates, 'trainers' were much more likely to be frequent bingers (76.3%; OR = 6.15).
Conclusions: A number of students report deliberately inducing alcohol tolerance, probably directly increasing the risk for alcohol poisoning and other acute harms and/or dependence. This phenomenon might additionally be applicable to other populations, and deserves further study and attention as a potential personal and public health risk. Prevention efforts might aim to reduce the perceived importance of heavy-drinking abilities.
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http://dx.doi.org/10.1111/j.1360-0443.2010.03042.x | DOI Listing |
Front Psychiatry
December 2024
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Introduction: Excessive alcohol use is a major public health concern, for which internet interventions have shown to be effective. Group-average effects may however mask substantial inter-individual variations in changes; identifying predictors of this variation remains an important research question. Biological sex is associated with pharmacokinetic differences in alcohol tolerance, which is reflected in many national guidelines recommending sex-specific thresholds for excessive drinking.
View Article and Find Full Text PDFPeerJ
January 2025
Faculty of Agricultural Sciences, University of the Punjab, Lahore, Punjab, Pakistan.
The continuous contamination of heavy metals (HMs) in our ecosystem due to industrialization, urbanization and other anthropogenic activities has become a serious environmental constraint to successful crop production. Lead (Pb) toxicity causes ionic, oxidative and osmotic injuries which induce various morphological, physiological, metabolic and molecular abnormalities in plants. Polyethylene glycol (PEG) is widely used to elucidate drought stress induction and alleviation mechanisms in treated plants.
View Article and Find Full Text PDFNutrients
January 2025
College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
Ice plant () is a vegetable with various therapeutic uses, one of which is its ability to prevent diabetes. The present study examined the insulin secretion effect related to the mechanism of action of ice plant extract (IPE) and its active compound D-pinitol in a rat insulin-secreting β-cell line, INS-1, as well as in diabetic rats. : The glucose-stimulated insulin secretion (GSIS) test and Western blotting were used to measure GSIS.
View Article and Find Full Text PDFFoods
January 2025
Science Center for Future Foods, Jiangnan University, Wuxi 214122, China.
This study evaluates the stress tolerance and metabolic adaptability of twelve yeast strains, including eleven commercial strains from Wyeast Laboratories and one prototrophic laboratory strain, under industrially relevant conditions. Yeast strains were assessed for their fermentation performance and stress responses under glucose limitation, osmotic stress, acid stress, elevated ethanol concentrations, and temperature fluctuations. Results revealed significant variability in glucose consumption, ethanol production, and stress tolerance across strains.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
α-Hydroxy ketones are a crucial class of organic compounds prevalent in natural products and pharmaceutical molecules. The CO-promoted hydration of propargylic alcohols is an efficient method for the synthesis of α-hydroxy ketones. Herein, an ionic liquid (IL) was designed to catalyze this reaction individually under atmospheric CO pressure, volatile organic solvents, and additives.
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