AI Article Synopsis
- Researchers studied extracts from Blumea riparia DC. to assess their impact on blood clotting and hemostasis in mice.
- The ethyl acetate (EtOAc) fraction notably decreased both blood clotting time and tail bleeding time, indicating enhanced coagulation.
- Key phenolic acids (vanillic, p-coumaric, and protocatechuic) demonstrated procoagulant effects and improved uterine contractions, suggesting they work through different mechanisms to promote blood coagulation.
Article Abstract
The effects of extracts of the aerial part of Blumea riparia DC. and their phenolic acids on hemostasis were evaluated. The EtOAc fraction showed significantly reduced blood clotting time (CT) and tail bleeding time of transection (BT) of mice in vivo. This fraction contained vanillic acid (1), syringic acid (2), p-coumaric acid (3), caffeic acid (4), and protocatechuic acid (5). Compound 1 reduced prothrombin time (PT), and strengthened mice uterine contractions. Compound 3 reduced CT and the activated partial thromboplastin time (APTT). Compound 5 reduced CT and increased the frequency of mice uterine contraction in a dose-dependent manner. Compound 2 reduced APTT. Compound 4 remarkably strengthened uterine contraction. Taken together, these data suggest that compounds 1, 3, and 5 possess procoagulant activity which jointly synergize blood coagulation via different mechanisms.
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