Liquiritigenin (7,4'-dihydroxyflavanone), isolated from the roots of Glycyrrhiza glabra, was derivatized to liquiritigenin 7, 4'-diacetate, liquiritigenin 4'-acetate, isoliquiritigenin, and liquiritigenin 7, 4'-dibenzoate. All these derivatives were evaluated for in vitro hepatoprotective activity against D-galactosamine-lipopolysaccharide(GalN/LPS) induced toxicity. In-vitro hepatotoxicity was manifested by a significant increase (P < 0.05) in liver toxicity biomarkers (SGPT, SGOT, ALKP, triglyceride, LPO, NO and LDH). The level of biomarkers in the treatment groups was significantly decreased (P < 0.05) when compared with the GalN/LPS group. The results revealed that isoliquiritigenin exhibited better hepatoprotective activity than liquiritigenin and its derivatives.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Uncovering the therapeutic potential of green pea waste in breast cancer: a multi-target approach utilizing LC-MS/MS metabolomics, molecular networking, and network pharmacology.
BMC Complement Med Ther
October 2024
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Unlabelled: BACKGROUND PISUM SATIVUM: (PS) is a universal legume plant utilized for both human and animal consumption, particularly its seeds, known as green peas. The processing of PS in food industries and households produces a significant amount of waste that needs to be valorized.
Methods: In this study, the metabolite profiles of the 70% ethanolic extracts of PS wastes, namely peels (PSP) and a combination of leaves and stems (PSLS), were investigated by liquid chromatography-electrospray ionization-quadrupole time-of-flight tandem mass spectrometry (LC-ESI-QTOF-MS/MS) followed by molecular networking.
Exploring the Role of Licorice and Its Derivatives in Cell Signaling Pathway NF-B and MAPK.
J Nutr Metab
October 2024
National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan.
Article Synopsis
- - Licorice is a key herb in traditional Chinese medicine noted for its anti-inflammatory properties, thanks to its ability to inhibit inflammatory pathways and prevent activation of key inflammatory markers like TNF-α and IL-6.
- - Its bioactive compounds, such as glycyrrhetinic acid and liquiritigenin, play a crucial role by interfering with processes in the MAPK and NF-κB signaling pathways, which are vital in regulating inflammation.
- - Ongoing research aims to delve deeper into the molecular mechanisms of licorice's effects, enhancing its potential as a natural treatment for inflammatory disorders and exploring ways to improve its applications in clinical settings.
Hepatoprotective activity of medicinal plants, their phytochemistry, and safety concerns: a systematic review.
Z Naturforsch C J Biosci
September 2024
Department of Allied Sciences, Graphic Era Hill University, Society Area, Clement Town, Dehradun, 248002, Uttarakhand, India.
Medicinal plants and their derivatives represent a promising reservoir of remedies for various ailments. Especially secondary metabolites of these plants, including alkaloids, flavonoids, phenolic compounds, terpenoids, steroids, saponins, tannins, and anthraquinones, play crucial roles in hepatoprotection. Studies have identified several prominent phytoconstituents, such as silymarin, quercetin, luteolin, glycyrrhizin, curcumin, gallic acid, chebulic acid, catechin, aloin, emodin, liquiritin, liquiritigenin, cudraflavone B, and karaviloside, as effective agents for addressing hepatotoxicity.
View Article and Find Full Text PDFWidely Targeted Metabolomics Provides New Insights into Nutritional Profiling and Reveals the Flavonoid Pathway of Pea ( L.).
Foods
June 2024
Hubei Key Laboratory of Food Crop Germplasm and Genetic Improvement, Food Crops Institute, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
To learn more about the nutritional composition and health benefits for human consumers of peas, we used a widely targeted metabolomics-based approach to reveal the metabolite components from three main varieties, and a total of 1095 metabolites were identified. A comparison of 487 differentially accumulated metabolites shared among three varieties of fresh and dried peas found most of the amino acids and derivatives were downregulated and most of the lipids and flavonoids were upregulated in dried peas. Furthermore, comparing the main nutrient profiles exclusively showed that there were few differences in free fatty acids, sugars, vitamins, and alkaloids between dried and fresh peas.
View Article and Find Full Text PDFHeterologous biosynthesis of medicarpin using engineered .
Synth Syst Biotechnol
December 2023
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, China.
Medicarpin is an important bioactive compound with multiple medicinal activities, including anti-tumor, anti-osteoporosis, and anti-bacterial effects. Medicarpin is associated with pterocarpans derived from medicinal plants, such as , Fisch., and L.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!