AI Article Synopsis
- The study aimed to investigate the histamine content in the brains of adult rats that had been treated neonatally with a serotonin neurotoxin (5,7-DHT) and how histamine receptor antagonists affect their behavior.
- At 10 weeks old, the researchers measured serotonin levels and histamine levels in various brain regions using specific techniques, and they studied the rats' behaviors, including locomotion and exploration.
- The results indicated that serotonin levels were significantly reduced due to the neurotoxin treatment, which also led to decreased histamine content and altered behavioral responses to certain receptor antagonists, highlighting the relationship between the serotonin system and histamine receptor activity in influencing behavior.
Article Abstract
The aim of this study was to determine histamine content in the brain and the effect of histamine receptor antagonists on behavior of adult rats lesioned as neonates with the serotonin (5-HT) neurotoxin 5,7-dihydroxytryptamine (5,7-DHT). At 3 days after birth Wistar rats were pretreated with desipramine (20 mg/kg ip) before bilateral icv administration of 5,7-DHT (37.5 μg base on each side) or saline-ascorbic (0.1%) vehicle (control). At 10 week levels of 5-HT and its metabolite 5-hydroxyindole acetic acid (5-HIAA) were determined in frontal cortex, striatum, and hippocampus by an HPLC/ED technique. In the hypothalamus, frontal cortex, hippocampus and medulla oblongata, the level of histamine was analyzed by an immunoenzymatic method. Behavioral observations (locomotion, exploratory-, oral-, and stereotyped activity) were performed, and effects of DA receptor agonists (SKF 38393, apomorphine) and histamine receptor antagonists S(+)chlorpheniramine (H(1)), cimetidine (H(2)), and thioperamide (H(3)) were determined. We confirmed that 5,7-DHT profoundly reduced contents of 5-HT and 5-HIAA in the brain in adulthood. Histamine content was also reduced in all examined brain regions. Moreover, in 5,7-DHT-lesioned rats the locomotor and oral activity responses to thioperamide were altered, and apomorphine-induced stereotype was intensified. From the above, we conclude that an intact central serotoninergic system modulates histamine H(3) receptor antagonist effects on the dopaminergic neurons in rats.
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| http://dx.doi.org/10.1007/s12640-010-9217-8 | DOI Listing |
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