Peste des petits ruminants virus is a member of Morbillivirus Paramyxoviridae. The complete genome of a Peste des petits ruminants virus (PPRV) isolate, China/Tib/07 was sequenced and molecular characteristics was analyzed. The internal sequences of the virus genome were amplified by RT-PCR with primers designed according to the published data in GenBank, while the sequences of the 3' and 5' ends of the genome were determined by RACE. Amplification products were directly sequenced,assembled and analyzed with DNAStar4.0. Results showed that China/Tib/07 genome consisted of 15 948 nucleotides in length, encoding six structural proteins and two non-structural proteins just like other known PPRV genomes. Phylogenetically, the virus genome shared homology of 91.6%-98.1% with Southwest Asian isolates among PPRV strains and the highest homology of 64.3% with rinderpest virus among morbillivirus members.
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Viruses
November 2024
College of Veterinary Science, Assam Agricultural University, Guwahati 781022, Assam, India.
Heliyon
December 2024
Department of Mathematics, University of Gondar, Gondar, Ethiopia.
Peste des Petits Ruminants (PPR) is a highly contagious transboundary viral disease of small ruminants with significant economic implications caused by the Peste des Petits Ruminants virus. This study employs mathematical modeling to investigate the impact of imperfect PPR vaccines and restocked small ruminants on the transmission dynamics of PPR. A deterministic mathematical model is developed by incorporating vaccinated and restocked subpopulations into the classical SEIR model.
View Article and Find Full Text PDFVet Med Sci
January 2025
Chongqing Three Gouges Vocational College, College of Animal Science & Technology, Wanzhou, China.
Peste des petits ruminants virus (PPRV), a single-stranded negative-sense RNA virus with an envelope, belongs to the Morbillivirus in the Paramyxoviridae family and is prevalent worldwide. PPRV infection causes fever, stomatitis, diarrhoea, pneumonia, abortion and other symptoms in small ruminants, with a high mortality rate that poses a significant threat to the sustainability and productivity of the small ruminant livestock sector. The PPRV virus particles have a diameter of approximately 400-500 nm and are composed of six structural proteins: nucleocapsid protein (N), phosphoprotein (P), envelope matrix protein (M), fusion protein (F), haemagglutinin protein (H) and large protein (L).
View Article and Find Full Text PDFFront Vet Sci
December 2024
Department of Health Biotechnology, Bio and Emerging Institute Technology, Addis Ababa, Ethiopia.
Background: Peste des petits ruminants (PPR) is an acute or subacute, highly contagious, and economically important, transboundary disease of small ruminants caused by Peste des petits ruminants virus (PPRV).
Objectives: The objective of this study was to determine the seroconversion rate in PPR vaccinated flock of sheep (Sekela district) and the seroprevalence of PPRV in unvaccinated flocks of sheep and goats (Yilmanadensa district).
Methods: A cross-sectional study was conducted from January to March 2022 in two selected districts of West Gojjam zone, Ethiopia.
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