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Assessing the toxicological impact of PET-MPs exposure on IVDD: Insights from network toxicology and molecular docking.
J Environ Manage
December 2024
Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, Gansu, 730030, PR China; The Second Clinical School, Lanzhou University, Lanzhou, Gansu, 730030, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou, Gansu, 730030, PR China. Electronic address:
Polyethylene terephthalate microplastics (PET-MPs) have emerged as a significant environmental concern due to their persistence and potential health hazards. Their role in degenerative diseases, particularly intervertebral disc degeneration (IVDD), remains poorly understood, highlighting the need for systematic evaluation of their molecular toxicity. In this study, network toxicology and molecular docking approaches were applied to investigate the toxicological mechanisms of PET-MPs-induced IVDD.
View Article and Find Full Text PDFTracking SARS-CoV-2 variants in wastewater in San Pedro de la Paz, Chile.
J Water Health
December 2024
Centro de Vigilancia de Aguas Residuales, Centinela Biobío, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción, Chile; Laboratorio de Investigación en Ciencias Biomédicas, Departamento de Ciencias Básicas y Morfología, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción, Chile E-mail:
Studies have shown the presence of SARS-CoV-2 in the stool of both symptomatic and asymptomatic COVID-19 patients, enabling wastewater-based surveillance (WBS) to complement clinical monitoring. The emergence of variants can enhance viral transmissibility, highlighting the need for ongoing surveillance to detect and control infectious diseases. This study aimed to detect SARS-CoV-2 variants in wastewater from a treatment plant in San Pedro de la Paz, Chile, between January and November 2021.
View Article and Find Full Text PDFFacile Hydrothermal Assisted Basic Catalyzed Sol Gel Synthesis for Mesoporous Silica Nanoparticle from Alkali Silicate Solutions Using Dual Structural Templates.
Gels
December 2024
Chemistry Department, Faculty of Science, Taibah University, Medina Munwarah 42353, Saudi Arabia.
This work presents a novel hydrothermally aided sol-gel method for preparation of mesoporous silica nanoparticles (MSNs) with a narrow particle size distribution and varied pore sizes. The method was carried out in alkaline media in presence of polyethylene glycol (PEG) and cetyltrimethylammonium chloride (CTAC) as dual templates and permitted the synthesis of spherical mesoporous silica with a high surface area (1011.42 m/g).
View Article and Find Full Text PDFX-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy.
Biomacromolecules
December 2024
School of Chemistry, Xi'an Key Laboratory of Sustainable Polymer Materials, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, China.
X-ray-induced photodynamic therapy (XPDT) can penetrate deeply into the tumor tissues to overcome the disadvantage of conventional PDT. However, the therapeutic efficacy of XPDT in cancer therapy is still restricted due to the insufficient reactive oxygen species (ROS) generation at a relatively low irradiation dosage. Herein, we present the tumor pH and ROS-responsive polyprodrug micelles to load the X-ray photosensitizer verteporfin (VP) as an ROS production enhancer.
View Article and Find Full Text PDFFA-PEG Modified ZIF(Mn) Nanoparticles Loaded with Baicalin for Imaging-Guided Treatment of Melanoma in Mice.
Int J Nanomedicine
December 2024
Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, 261031, People's Republic of China.
Background: Melanoma is an aggressive skin tumor with limited therapeutic options due to rapid proliferation, early metastasis, and poor prognosis. Baicalin (BA), a natural flavonoid, shows promise in inducing ferroptosis and apoptosis but faces challenges of poor solubility and bioavailability. To address these issues, we developed a multifunctional drug delivery system: manganese-doped ZIF-8 nanoparticles (ZIF(Mn)) loaded with BA and modified with folic acid (FA) and polyethylene glycol (PEG).
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