AI Article Synopsis
- - The study explores the creation and structure-activity relationship (SAR) of specific DPP4 inhibitors, focusing on aminomethyl-substituted imidazolopyrimidines with different aryl group attachments.
- - Starting with Compound 1, which consists of non-interchangeable atropisomers, the research investigates how varying substituent patterns and types influence the effectiveness of the inhibitors.
- - The findings highlight the importance of stereochemistry and the arrangement of substituents in determining the potency of these DPP4 inhibitors.
Article Abstract
The synthesis and SAR of aminomethyl-substituted imidazolopyrimidine DPP4 inhibitors bearing varied pendant aryl groups is described. Compound 1, which exists as a separable mixture of non-interconvertible atropisomers was used as the starting point for investigation. The effects of substituent pattern and type as well as stereochemical effects on inhibitor potency are discussed.
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| http://dx.doi.org/10.1016/j.bmcl.2010.08.090 | DOI Listing |
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