AI Article Synopsis
- CD40 ligand (CD40L) is linked to atherosclerosis and the worsening of plaque, and this study investigates its levels in coronary arteries (CA) and their relationship with cardiovascular events in acute myocardial infarction (AMI) patients.
- Blood samples were taken from different sites in 68 AMI patients, showing significantly higher CD40L levels in the CA compared to peripheral veins and the aorta.
- High CD40L levels in CA correlate with more severe heart damage and an increased risk of future cardiovascular events, suggesting that CD40L could serve as a useful predictive marker for AMI prognosis.
Article Abstract
Objective: CD40 ligand (CD40L) plays a crucial role in atherogenesis and plaque destabilization. The purpose of this study was to clarify the association of CD40L levels in the culprit coronary arteries (CA) with the subsequent cardiovascular events in patients with acute myocardial infarction (AMI).
Methods: We enrolled 68 patients with AMI whose CA were treated using thrombectomy devices. Blood samples were collected from the peripheral veins (PV), the ascending aortae (AO) and CA.
Results: CD40L levels in the CA were significantly greater than those in the PV and AO. Statistical analyses revealed that CD40L levels in CA correlated positively with the corrected TIMI frame counts and maximal serum creatine kinase-MB in throughout clinical course, and inversely with myocardial blush grade and left ventricular ejection fraction 6 months after AMI. In logistic regression analyses, the group with high CD40L levels in CA was associated with an 8.58-fold increase in the odds of a cardiovascular event rate compared with the group with low CD40L levels.
Conclusions: In patients with AMI, enhanced CD40L levels in CA might affect myocardial perfusion, myocardial damage, and subsequent cardiovascular events, and could be a predictive marker for the prognosis of AMI.
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| http://dx.doi.org/10.1016/j.atherosclerosis.2010.07.044 | DOI Listing |
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