Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12185-010-0676-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immature granulocytes and neutrophil-to-lymphocyte ratio as markers of treatment response in subacute thyroiditis.
Arch Endocrinol Metab
October 2024
Division of Endocrinology and Metabolism Kahramanmaraş Sütçü Iman University Faculty of Medicine Kahramanmaraş Turkey Division of Endocrinology and Metabolism, Kahramanmaraş Sütçü Iman University Faculty of Medicine, Kahramanmaraş, Turkey.
Objective: Subacute thyroiditis is also known as subacute granulomatous thyroiditis, giant cell thyroiditis, painful thyroiditis, and De Quervain's thyroiditis. Immature granulocytes (IG) and neutrophil-to-lymphocyte ratio (NLR) are new inflammatory markers that are easily detected in routine complete blood count (CBC) tests. The aim of this study was to investigate the role of IG and NLR as markers of treatment response in patients with subacute thyroiditis.
View Article and Find Full Text PDFTHIN AND ULTRATHIN STRUCTURE OF ENVELOPES OF STEPHANOSTOMUM BACCATUM (TREMATODA: ACANTHOCOLPIDAE) METACERCARIAE IN YELLOWFIN SOLE, LIMANDA ASPERA.
J Parasitol
October 2024
Institute of Biological Problems of the North FEB RAS, Portovaya str. 18, 685000 Magadan, Russia.
Article Synopsis
- The study analyzes the envelopes (capsule and cyst) of metacercariae from the parasite Stephanostomum baccatum in the yellowfin sole using light and transmission electron microscopy.
- The cyst has two layers: an outer thin electron-dense layer and an inner looser layer containing varying dense bodies. The capsule, derived from host cells, also features two distinct layers made up of degenerated cell debris, lipid droplets, and a variety of immune cells.
- Findings highlight unique structural characteristics of the capsules that differentiate S. baccatum from similar metacercariae in other fish species, enhancing understanding of parasite biology and implications for host-parasite interactions.
Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue.
Blood
December 2024
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Article Synopsis
- Juvenile xanthogranuloma (JXG) is a type of skin tumor mostly found in children, but some cases occur in other parts of the body, and their genetic causes are not fully understood.* -
- A study analyzed 16 children and 5 adults with extracutaneous JXG using advanced sequencing, finding that numerous genetic alterations, especially related to kinase fusions, were present in most children.* -
- The findings indicate that while surgery is common for treatment, some cases can regress on their own, and specific genetic alterations could help inform better treatment options in the future.*
Article Synopsis
- TGCT is a challenging tumor to treat, primarily managed through surgery, but there are few options for patients who can't have surgery; this study investigates vimseltinib, a new oral medication targeting the CSF1 receptor.
- Conducted as a phase I/II trial with 69 patients (37 with various malignant tumors and 32 with TGCT), the study aimed to evaluate the safety, tolerability, and pharmacokinetics of vimseltinib, while looking at its potential effectiveness.
- The results showed that vimseltinib was generally well tolerated with a recommended dose of 30 mg taken twice a week, and achieved a 72% objective response rate in TGCT patients, demonstrating promising
Activated eosinophils in early life impair lung development and promote long-term lung damage.
Mucosal Immunol
October 2024
Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address:
Exaggeration of type 2 immune responses promotes lung inflammation and altered lung development; however, eosinophils, despite expansion in the postnatal lung, have not been specifically assessed in the context of neonatal lung disease. Furthermore, early life factors including prematurity and respiratory infection predispose infants to chronic obstructive pulmonary disease later in life. To assess eosinophils in the developing lung and how they may contribute to chronic lung disease, we generated mice harboring eosinophil-specific deletion of the negative regulatory enzyme SH2 domain-containing inositol 5' phosphatase-1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!