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Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes. | LitMetric
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Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes.

Jeroen Van den Bossche Wafa' T Al-Jamal Bowen Tian Antonio Nunes Chiara Fabbro Alberto Bianco Maurizio Prato Kostas Kostarelos

Chem Commun (Camb)

Nanomedicine Laboratory, Centre for Drug Delivery, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK WC1N 1AX.

Published: October 2010

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.

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 Source
http://dx.doi.org/10.1039/c0cc02092cDOI Listing

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