Background/aim: Chronic illness can be distressing for patients. It confronts them with the challenge of having to cope with their life and of having to adjust their self-image. Nevertheless, patients often experience that they go through a process of personal growth. Although there is empirical proof of the potential that coping with severe illness has with regard to personal growth, fairly little is known about the conditions that bring about such a development. Based on a singlecase study of fibromyalgia (FM) from Germany, the paper reveals the potential of a biographical approach for understanding the process of personal growth in chronic illness.
Methods: The case is part of a qualitative study on the occurrence of biographical transformation in severe illnesses. A narrative, biographical interview was conducted with the patient. The analysis takes objective biographical data as well as the subjective experience of the patient into account.
Results: Our analysis is confirmed by qualitative studies on the subjective experience of FM. Although these studies report a favorable development with some FM sufferers, they neither investigate its significance for the life of the patient nor the factors that make personal growth possible. We tried to identify biographical resources and personal strategies of the patient that facilitated her inner growth.
Conclusion: A biographical approach is a way towards understanding individual growth in the face of severe suffering. By including the patients' objective life data as well as their subjective experiences, deeper insights into the process of personal growth can be gained.
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http://dx.doi.org/10.1159/000317848 | DOI Listing |
ACS Nano
January 2025
Medical Research Center, The First Affiliated Hospital of Zhengzhou University, The Center of Infection and Immunity, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Tumor-specific T cells play a vital role in potent antitumor immunity. However, their efficacy is severely affected by the spatiotemporal orchestration of antigen-presentation as well as the innate immune response in dendritic cells (DCs). Herein, we develop a minimalist nanovaccine that exploits a dual immunofunctional polymeric nanoplatform (DIPNP) to encapsulate ovalbumin (OVA) via electrostatic interaction when the nanocarrier serves as both STING agonist and immune adjuvant in DCs.
View Article and Find Full Text PDFJ Int Neuropsychol Soc
January 2025
Department of Brain Health, University of Nevada, Las Vegas, NV, USA.
Objective: Neuropsychiatric symptoms (NPS) are considered diagnostic and prognostic indicators of dementia and are attributable to neurodegenerative processes. Little is known about the prognostic value of early NPS on executive functioning (EF) decline in Alzheimer's disease and related dementias (ADRD). We examined whether baseline NPS predicted the rate of executive function (EF) decline among older adults with ADRD.
View Article and Find Full Text PDFBiomed Res Int
January 2025
Center for Personalized Nanomedicine, Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia.
Environmental pollution has been a significant concern for the last few years. The leather industry significantly contributes to the economy but is one of Bangladesh's most prominent polluting industries. It is also responsible for several severe diseases such as cancer, lung diseases, and heart diseases of leather workers because they use bleaching agents and chemicals, and these have numerous adverse effects on human health.
View Article and Find Full Text PDFF1000Res
January 2025
Facultad de educación, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Background: The objective of this study was to determine the conditioning factors for scientific research productivity in university students of health sciences.Scientific productivity, in addition to making visible the generation of new knowledge, contributes to the well-being of the population and provides feedback to the scientific community in terms of methodologies, perspectives and results that help to break down barriers that delimit productivity in scientific research.
Methods: A cross-sectional analytical observational study was conducted.
Mater Today Bio
February 2025
Discipline of Mechanical, Manufacturing and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
Peripheral nerve repair (PNR) is a major healthcare challenge due to the limited regenerative capacity of the nervous system, often leading to severe functional impairments. While nerve autografts are the gold standard, their implications are constrained by issues such as donor site morbidity and limited availability, necessitating innovative alternatives like nerve guidance conduits (NGCs). However, the inherently slow nerve growth rate (∼1 mm/day) and prolonged neuroinflammation, delay recovery even with the use of passive (no-conductive) NGCs, resulting in muscle atrophy and loss of locomotor function.
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