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Bis-Iridoid Glycosides and Triterpenoids from and Their Potential as Inhibitors of ACC1 and ACL.
Molecules
December 2024
Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, School of Pharmaceutical Sciences, Taizhou University, Taizhou 318000, China.
A comprehensive phytochemical investigation of the twigs/leaves and flower buds of , a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (- and -), 20 triterpenoids (, , and -), and 8 phenylpropanoids (-). Among these, amabiliosides A () and B () represent previously undescribed bis-iridoid glycosides, while amabiliosides C () and D () feature a unique bis-iridoid-monoterpenoid indole alkaloid scaffold with a tetrahydro--carboline-5-carboxylic acid moiety.
View Article and Find Full Text PDFExploring the Differential Diagnosis of Adrenal Adenoma in the Context of Situs Ambiguous: A Clinical Case Study.
Medicina (Kaunas)
December 2024
Medical College, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Situs anomalies, including situs inversus and situs ambiguous (SAMB), are rare congenital conditions typically noted in pediatric populations, with SAMB being particularly uncommon in adults. This case study addresses the incidental discovery of situs ambiguous with polysplenia in a 65-year-old man evaluated for suspected adrenal adenoma. The patient's medical history included benign prostatic hyperplasia and tuberculous pleurisy.
View Article and Find Full Text PDFMolecular Subtypes of Vulvar Squamous Cell Carcinoma: The Significance of HPV-Independent/p53 Wild Type.
Cancers (Basel)
December 2024
Division of Gynecologic, Breast and Perinatal Pathology, Institute of Pathology, University Hospital Leipzig, D-04103 Leipzig, Germany.
Vulvar carcinoma is a rare disease, meeting the criteria for a "rare cancer", but its incidence is increasing, especially in women <60 years of age. Squamous cell carcinoma (VSCC) accounts for the overwhelming majority of vulvar carcinomas and is the focus of this review. As with many cancers, the increased understanding of molecular events during tumorigenesis has led to the emergence of the molecular subclassification of VSCC, which is subclassified into tumors that arise secondary to high-risk human papillomavirus infection (HPV-associated, or HPVa) and those that arise independently of HPV (HPVi), most commonly in the setting of a chronic inflammatory condition of the vulvar skin.
View Article and Find Full Text PDFHybrid Achilles tendon repair with gastrocnemius fascia turn-down flap for fracture of ossified Achilles tendon.
Int J Surg Case Rep
January 2025
Department of Orthopaedics, School of Medicine, University of Phayao, Phayao, Thailand. Electronic address:
Introduction And Importance: Fractures of ossified Achilles tendons are rare and often associated with repetitive jumping and sprinting in young athletes. Although the exact cause of Achilles tendon ossification is unclear, prior trauma and surgery are common contributing factors.
Case Presentation: A 47-year-old male recreational athlete experienced acute pain in his right heel after a football game.
FDG PET-CT missed tibial metastasis in head and neck cancer, case report and systematic review.
Int J Surg Case Rep
December 2024
Bibliothèque des Sciences de la Santé, Université libre de Bruxelles (ULB), Campus Erasme - CP 607, Route de Lennik, 808, 1070 Bruxelles, Belgium. Electronic address:
Introduction: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common type of cancer in the world. Metastases occur in up to 40 % of cases and bones are the second most frequent site. Metastases in extremities are uncommon with very few publications covering distal lower-limb bone metastasis.
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