Survival of women with colon cancer in relation to precancer anthropometric characteristics: the Iowa Women's Health Study.

Cancer Epidemiol Biomarkers Prev

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota 55455, USA.

Published: September 2010

Background: We hypothesized that precancer anthropometric variables are associated with mortality among women who developed colon cancer in a prospective cohort, the Iowa Women's Health Study (IWHS).

Methods: From 1986 to 2005, 1,096 incident cases of colon cancer were identified (mean age at diagnosis, 73 years). Anthropometric characteristics were self-measured before colon cancer diagnosis (in 1986). Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for all-cause and colon-cancer mortality, adjusted for age at cancer diagnosis, stage, education, smoking status, and pack-years of smoking.

Results: During the follow-up of up to 20 years, 493 women died; 289 had colon cancer as the underlying cause. The HRs of all-cause death were increased for the highest versus lowest tertile for weight (HR, 1.39; 95% CI, 1.10-1.76; P trend = 0.005); waist to hip ratio (WHR; HR, 1.36; 95% CI, 1.08-1.72; P trend = 0.008), and waist (HR, 1.45; 95% CI, 1.15-1.82; P trend = 0.001). Compared with that for body mass index (BMI) of 18.5 to 24.9 kg/m(2), HRs were increased for BMI >or=30 kg/m(2) (HR, 1.45; 95% CI, 1.14-1.85) and for the few women with BMI <18.5 kg/m(2) (HR, 1.89; 95% CI, 1.01-3.53). Colon cancer mortality was positively associated with WHR and waist: HR, 1.37 (95% CI, 1.02;1.85; P trend = 0.04) and 1.34 (95% CI, 1.01-1.80; P trend = 0.05), respectively, for the highest versus lowest tertile.

Conclusion: Greater precancer anthropometric measures and BMI <18.5 kg/m(2) predicted poorer survival among colon cancer patients. Higher abdominal adiposity measured by WHR and waist was associated with increased risk of colon cancer death.

Impact: Prediagnostic obesity may be a modifiable risk factor for death in colon cancer patients.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945249PMC
http://dx.doi.org/10.1158/1055-9965.EPI-10-0522DOI Listing

Publication Analysis

Top Keywords

colon cancer
20
precancer anthropometric
8
anthropometric characteristics
8
iowa women's
8
women's health
8
health study
8
cancer diagnosis
8
145 95%
8
cancer
6
95%
6

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!