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Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage.
Physiol Rep
January 2025
Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan.
While autonomic dysregulation and repolarization abnormalities are observed in subarachnoid hemorrhage (SAH), their relationship remains unclear. We aimed to measure skin sympathetic nerve activity (SKNA), a novel method to estimate stellate ganglion nerve activity, and investigate its association with electrocardiogram (ECG) alterations after SAH. We recorded a total of 179 SKNA data from SAH patients at three distinct phases and compared them with 20 data from controls.
View Article and Find Full Text PDFChanges in the Phenotype and Metabolism of Peritoneal Macrophages in Mucin-2 Knockout Mice and Partial Restoration of Their Functions In Vitro After L-Fucose Treatment.
Int J Mol Sci
December 2024
Physical Engineering Faculty, Novosibirsk State Technical University, 630073 Novosibirsk, Russia.
In the development of inflammatory bowel disease (IBD), peritoneal macrophages contribute to the resident intestinal macrophage pool. Previous studies have demonstrated that oral administration of L-fucose exerts an immunomodulatory effect and repolarizes the peritoneal macrophages in vivo in mice. In this study, we analyzed the phenotype and metabolic profile of the peritoneal macrophages from mice, as well as the effect of L-fucose on the metabolic and morphological characteristics of these macrophages in vitro.
View Article and Find Full Text PDFA Probabilistic Modeling Framework for the Prediction of Spontaneous Premature Beats and Reentry Initiation.
Heart Rhythm
January 2025
Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA. Electronic address:
Background: Spontaneously occurring life threatening reentrant arrhythmias result when a propagating premature beat encounters a region with significant dispersion of refractoriness. Although localized structural tissue heterogeneities and prescribed cell functional gradients have been incorporated into computational electrophysiological models, a quantitative framework for the evolution from normal to abnormal behavior that occurs via disease is lacking.
Objective: The purpose of this study was to develop a probabilistic modeling framework that represents the complex interplay of cell function and tissue structure in health and disease which predicts the emergence of premature beats and the initiation of reentry.
Poincaré plot analysis of ECG uncovers beneficial effects of omaveloxolone in a mouse model of Friedreich's ataxia.
Heart Rhythm
January 2025
Department of Molecular Biosciences, University of California, Davis, CA, USA; Department of Basic Sciences, California Northstate University, Elk Grove, CA. Electronic address:
Background: Friedreich's ataxia (FA) is a rare inherited neuromuscular disorder, where most patients die from lethal cardiomyopathy and arrhythmias. Mechanisms leading to arrhythmic events in FA patients are poorly understood.
Objective: This study aims to examine cardiac electrical signal propagation in mouse model of FA with severe cardiomyopathy and evaluate effects of omaveloxolone (OMAV), the first FDA-approved therapy.
Interpretation and management of T wave inversion in athletes: An expert opinion statement of the Italian Society of Sports Cardiology (SICSPORT).
Int J Cardiol
January 2025
Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padova, Italy. Electronic address:
Article Synopsis
- T wave inversion (TWI) on ECG is common in athletes and can signal either harmless changes or serious heart issues, requiring careful interpretation.
- Understanding TWI involves considering its location, associated symptoms, and patient demographics, which help differentiate between physiological adaptations and pathological conditions.
- The management of athletes with TWI includes thorough diagnostic evaluations, follow-ups, and careful considerations regarding sports participation to prioritize athlete safety without excessive restrictions.
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