The Kessler-10 (K10) questionnaire was developed as a screening instrument for nonspecific psychological distress. Although it was validated using epidemiological samples, it is increasingly being used in clinical settings. We sought to determine whether the factor structure of the K10 as established in epidemiological samples, could be replicated in a sample of treatment seeking adults. We used confirmatory factor analysis to investigate two established models of the factor structure of the K10 in a sample of clinic attendees. Neither the single factor model of Kessler et al., Psychol Med. 2002;32:959-976, nor the multifactorial model of Brooks et al., Psychol Assess. 2006;18:62-70 fitted the data. Respecification of the Kessler et al. model to reduce item redundancy did not result in adequate fit. These findings call into question the construct validity of the K10 in treatment seeking samples, and the suitability of the scale for clinical settings may need to be reconsidered.
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http://dx.doi.org/10.1097/NMD.0b013e3181ef1f16 | DOI Listing |
Front Psychol
January 2025
Faculty of Sports Science and Coaching, Sultan Idris Education University, Tanjong Malim, Malaysia.
Introduction: This study aimed to investigate the relationship between need-supportive coaching behavior, subjective task value, goal orientation, and engagement among Chinese high school football players and propose four research hypotheses better to understand the determinants and mechanisms of athlete engagement.
Methods: Participants were 385 Chinese high school football players (228 boys; 157 girls; Mage = 16.07 years; SD = 1.
Lancet Reg Health West Pac
January 2025
Department of Medicine, National University of Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore.
Background: Little is known about the practices and resources employed by general practitioners (GPs) in Singapore to manage late-life depression. As the country is stepping up its efforts to promote collaborative care across community mental health and geriatric care, understanding GPs' current practices when managing late-life depression appears timely.
Methods: This qualitative descriptive study explored the perspectives on late-life depression of 28 private GPs practicing in Singapore through online semi-structured group and individual interviews.
EClinicalMedicine
February 2025
Department of Breast and Gynaecological Surgery, Institut Curie, Paris, France.
Background: Randomized clinical trials (RCTs) are fundamental to evidence-based medicine, but their real-world impact on clinical practice often remains unmonitored. Leveraging large-scale real-world data can enable systematic monitoring of RCT effects. We aimed to develop a reproducible framework using real-world data to assess how major RCTs influence medical practice, using two pivotal surgical RCTs in gynaecologic oncology as an example-the LACC (Laparoscopic Approach to Cervical Cancer) and LION (Lymphadenectomy in Ovarian Neoplasms) trials.
View Article and Find Full Text PDFJ Inflamm Res
January 2025
Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Background: Chronic kidney disease (CKD) is a progressive condition that arises from diverse etiological factors, resulting in structural alterations and functional impairment of the kidneys. We aimed to establish the Anoikis-related gene signature in CKD by bioinformatics analysis.
Methods: We retrieved 3 datasets from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs), followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) of them, which were intersected with Anoikis-related genes (ARGs) to derive Anoikis-related differentially expressed genes (ARDEGs).
Cytotechnology
April 2025
Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Because acute kidney injuries (AKI) are one of the critical health problems worldwide, studies on the risk factors, mechanisms, and treatment strategies seem necessary. Glycerol (GLY), known to induce cell necrosis via myoglobin accumulation in renal tubules, is widely used as an AKI model. This study aimed to evaluate the protective effects of gallic acid (GA) against GLY-induced AKI.
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