Background: drug intake is associated with the risk of drug-related problems (DRPs), e.g. the intake of PIM.
Objective: the proportion of potentially inappropriate medication (PIM) taken by elderly people was analysed.
Design: community-based, prospective cohort study.
Setting: ambulatory health-care sector in a German rural area.
Subjects: seven hundred and forty-four patients with age >65 years and regular intake of drugs.
Methods: comprehensive home medication review (HMR) provided by specially qualified assistants of GP practices using electronic case reporting forms (eCRFs), and GP's diagnoses were extracted from patients' health records. Updated Beers' list of Fick et al. was used to detect PIM for patients >65 years and drug-condition interaction.
Results: a total of 18% (n= 134) of the patients received 163 inappropriate drugs. Out of these drugs, most prevalent PIM were benzodiazepine derivates (n= 45). Out of all drugs, 25 drug-condition interactions were identified. The intake of PIM was slightly associated with self-reported falls (: 0.1074; P= 0.0244). Multivariate logistic regression showed significant results for the number of taken substances (OR = 1.176; 95% CI 1.121-1.234, P< 0.001).
Conclusions: a high proportion of patients taking PIM in a community-based setting were investigated. Statistical associations with self-reported falls were found. Confounding may influence data. Further research to investigate findings is needed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ageing/afq106 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: The most effective way to treat patients following a first ICD therapy is unclear. We hypothesised that following first ICD therapy, combining different treatment strategies would be associated with a reduction in the risk of subsequent therapy compared to single strategies alone.
Methods: Data was collected from consecutive patients undergoing ICD implantation at King's College Hospital between January 2009 and December 2019.
Exploring Novel Antibiotics by Targeting the GroEL/GroES Chaperonin System.
ACS Pharmacol Transl Sci
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.
Infectious diseases have affected 13.7 million patients, placing a heavy burden on society. Furthermore, inappropriate and unrequited utilization of antibiotics has led to antimicrobial resistance worldwide.
View Article and Find Full Text PDFAssessment of inappropriate use of antibiotics and contributing factors in Awi Administrative Zone, Northwestern Amhara regional State, Ethiopia.
New Microbes New Infect
February 2025
Faculty of Agriculture, Dalhousie University, Nova Scotia, Canada.
Objectives: Antibiotic misuse is regarded as the single most significant factor contributing to resistance. Thus, this study aimed to evaluate the prevalence and risk variables linked to the inappropriate use of antibiotics in urban and rural districts of the Awi administrative zone community.
Methods: A total of 1194 rural and urban families, including individuals of various ages and genders from the study area were selected by a multistage stratified random sampling method for a comparative cross-sectional study conducted between December 2022 and June 2023.
identification of silent primycin biosynthetic gene clusters within the family .
Heliyon
January 2025
Institute of Biology, Faculty of Sciences, University of Pécs, H-7624, Pécs, Hungary.
In the global effort to discover or design new effective antibiotics to fight infectious diseases, the increasingly available multi-omics data with novel bioinformatics tools open up new horizons for the exploration of the genetic potential of bacteria to synthesize bioactive secondary metabolites. Rare actinomycetes are a prolific source of structurally diverse secondary metabolites that exhibit remarkable clinical and industrial importance. Recently several excellent genome mining tools have been available for identifying biosynthetic gene clusters, however in cases of poor-quality sequences and inappropriate genome assembly, these tools are not always able to identify the corresponding gene clusters.
View Article and Find Full Text PDFPredictors of Potentially Inappropriate Stimulant Prescribing Among Adults.
Pharmacoepidemiol Drug Saf
January 2025
Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Purpose: Increases in adult stimulant prescribing pose a potential risk due to the higher prevalence of contraindicated conditions among this population. We sought to identify patient, provider, and visit characteristics predictive of potentially inappropriate adult stimulant prescriptions.
Methods: We conducted a repeated cross-sectional study using the National Ambulatory Medical Care Survey, a nationally representative weighted sample of 5 453 702 723 ambulatory care visits from 2012 to 2019.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!