AI Article Synopsis
- Regulatory T cells (Tregs) play a key role in immune suppression during pregnancy and post-organ transplantation, particularly a specialized subset known as FoxP3(+)DR(+)-Tregs.
- Research shows that while the overall percentage of FoxP3(+)DR(+)-Tregs remains stable in certain conditions, their level of HLA-DR expression is significantly lower in women experiencing preterm labor and in kidney transplant rejection cases.
- Both groups showed a notable decrease in the suppressive activity of their Treg cells, suggesting that these specific Tregs may be crucial in preventing preterm labor and transplant rejection, indicating overlapping immunologic mechanisms in both processes.
Article Abstract
Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3(+)DR(+)-Tregs among the total CD4(+)CD127(low+/-)CD25(+)-Treg cell pool is critically involved in preterm labor induction and kidney transplant rejection as well. Compared to healthy pregnancies and non-rejecting kidney recipients, we found that the percentage of the FoxP3(+)DR(+)-Treg subset was not reduced, but that the level of HLA-DR expression of such Tregs was strongly diminished in preterm laboring women and in patients with acute renal allograft rejection. In addition, both patient collectives showed a significantly reduced suppressive activity of their circulating CD4(+)CD127(low+/-)CD25(+)-Treg cell pool. Our findings propose that the FoxP3(+)DR(+)-Treg subset may be decisively responsible for the suppressive activity of the total CD4(+)CD127(low+/-)CD25(+)-Treg cell pool and that the immunologic mechanisms leading to preterm labor necessitating preterm delivery may be similar to those leading to allograft rejection after transplantation.
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| http://dx.doi.org/10.1016/j.clim.2010.07.008 | DOI Listing |
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