Electron applicators and cut-outs have been used for some time in the delivery of electron beam therapy. A dual electron multileaf collimator (eMLC) consisting of upper and lower eMLCs was designed, and dose distributions of electron beams delivered by it were evaluated by Monte Carlo simulations by use of the EGSnrc Monte Carlo code. The percentage depth dose (PDD), dose profiles, dose gradient falloff (G), depth of maximum dose (R(100)), surface dose, bremsstrahlung background, beam flatness, and penumbra of the dual eMLC were evaluated and compared with those simulated and measured with the standard applicators inserted into the treatment head of the medical linear accelerator (linac). The results showed good agreement in most cases. Specifically, the flatness and penumbra obtained with the dual eMLC were better than those obtained with standard applicators. It is therefore possible to use the proposed dual eMLC in the delivery of electron beam therapy without the need for applicators and cut-outs. This will minimize the inconvenience of placing cut-outs on the patients; also, changes in the required field can be effected without the therapist going into the accelerator room when the dual eMLC is finally automated. The absence of a helium bag between the upper and lower eMLCs did not offer significant changes in the dosimetry parameters compared to the eMLC fitted with the helium bag.
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http://dx.doi.org/10.1007/s12194-009-0068-z | DOI Listing |
J Exp Zool A Ecol Genet Physiol
June 2012
Institute of Cell Biology, Heinrich-Heine-University, Düsseldorf, Germany.
Many tardigrade species resist harsh environmental conditions by entering anhydrobiosis or cryobiosis. Desiccation as well as freeze resistance probably leads to changes of the ionic balance that includes the intracellular calcium concentration. In order to search for protein modifications affecting the calcium homoeostasis, we studied the regulatory system controlling actin-myosin interaction of the eutardigrade Hypsibius klebelsbergi and identified full-length cDNA clones for troponin C (TnC, 824 bp), calmodulin (CaM, 1,407 bp), essential myosin light chain (eMLC, 1,015 bp), and regulatory myosin light chain (rMLC, 984 bp) from a cDNA library.
View Article and Find Full Text PDFRadiol Phys Technol
July 2010
Department of Medical Physics, University of Limpopo, Medunsa Campus, Medunsa, 0204, South Africa.
A dual electron multileaf collimator (eMLC) has recently been proposed and ascertained to be effective in the collimation of therapy electron beams. The EGSnrc Monte Carlo code has been used in the optimization of the dual eMLC by simulation of the Varian 2100C medical linear accelerator with the applicator completely replaced by the dual eMLC, and calculation of the dose distributions in a water phantom. The planar fluence results showed that the material combination of 2-cm-thick brass and 2-cm-thick tungsten (eMLCT1) as upper and lower eMLCs, respectively, offers minimal radiation leakage outside the treatment field.
View Article and Find Full Text PDFRadiol Phys Technol
July 2009
Department of Medical Physics, University of Limpopo, Medunsa Campus, Medunsa, South Africa.
Electron applicators and cut-outs have been used for some time in the delivery of electron beam therapy. A dual electron multileaf collimator (eMLC) consisting of upper and lower eMLCs was designed, and dose distributions of electron beams delivered by it were evaluated by Monte Carlo simulations by use of the EGSnrc Monte Carlo code. The percentage depth dose (PDD), dose profiles, dose gradient falloff (G), depth of maximum dose (R(100)), surface dose, bremsstrahlung background, beam flatness, and penumbra of the dual eMLC were evaluated and compared with those simulated and measured with the standard applicators inserted into the treatment head of the medical linear accelerator (linac).
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