In previous work we have observed that ovariectomy in rodents, a good model of mimicking human ovarian hormone loss, causes premature aging of the immune system. The prooxidative and inflammatory state that underlies the aging process is the base of that premature immunosenescence. It has been found that nutritional interventions with polyphenolic antioxidants constitute a good alternative to rejuvenate age-affected immune functions. In this study, we administered a diet supplemented with polyphenols (coming from soybean isoflavones and green tea) to sham-operated and ovariectomized mature mice for 15 weeks, until they reached a very old age. We have studied the effect of this supplementation on a broad range of parameters of immune function (in macrophages and lymphocytes) and oxidative stress (enzymatic and nonenzymatic antioxidant defences, oxidant compounds, and lipid peroxidation damage) in peritoneal leukocytes. The results showed that ovariectomy accelerates the age-related impairment of immune functions in very old mice as well as the oxidative and proinflammatory imbalance, and that the administration of soybean isoflavones and green tea improve the immune and redox state in these animals. Because the immune system is a good marker of health and a predictor of longevity, we suggest that an adequate nutritional treatment with polyphenols could be a highly recommended tool to fight against the detrimental effects of the lack of female sex hormones, through an improvement of the immune cell functions and redox state.

Download full-text PDF

Source
http://dx.doi.org/10.1089/rej.2010.1049DOI Listing

Publication Analysis

Top Keywords

green tea
12
immune
8
improve immune
8
immune function
8
immune system
8
immune functions
8
soybean isoflavones
8
isoflavones green
8
redox state
8
soybean green
4

Similar Publications

Comparison of the aquatic toxicity of diquat and its metabolites to zebrafish Danio rerio.

Sci Rep

December 2024

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China.

Diquat (DQ) is a non-selective, fast-acting herbicide that is extensively used in aquatic systems. DQ has been registered as the substitute for paraquat due to its lower toxicity. However, the widespread presence of DQ in aquatic systems can pose an ecological burden on aquatic organisms.

View Article and Find Full Text PDF

Intracerebral hemorrhage (ICH) is a common cerebrovascular disease characterized by a high incidence, disability rate, and mortality. Epigallocatechin gallate (EGCG), a key catechin compound found in green tea, has received increasing attention for its potential neuroprotective and therapeutic effects in neurological disorders. Studies have indicated that EGCG may influence various signaling pathways and molecular targets, including the inhibition of oxidative stress, reduction of inflammatory responses, suppression of cell apoptosis, regulation of cell survival, and enhancement of autophagy.

View Article and Find Full Text PDF

Tea bud detection technology is of great significance in realizing automated and intelligent plucking of tea buds. This study proposes a lightweight tea bud identification model based on modified Yolov5 to increase the picking accuracy and labor efficiency of intelligent tea bud picking while lowering the deployment pressure of mobile terminals. The following methods are used to make improvements: the backbone network CSPDarknet-53 of YOLOv5 is replaced with the EfficientNetV2 feature extraction network to reduce the number of parameters and floating-point operations of the model; the neck network of YOLOv5, the Ghost module is introduced to construct the ghost convolution and C3ghost module to further reduce the number of parameters and floating-point operations of the model; replacing the upsampling module of the neck network with the CARAFE upsampling module can aggregate the contextual tea bud feature information within a larger sensory field and improve the mean average precision of the model in detecting tea buds.

View Article and Find Full Text PDF

Regular Consumption of Black Tea Kombucha Modulates the Gut Microbiota in Individuals with and Without Obesity.

J Nutr

December 2024

Bioactive Compounds and Carbohydrates (BIOCARB) Research Group - Department of Food Science and Technology, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Viçosa, MG, 36570-900, Brazil. Electronic address:

Background: Kombucha, a fermented beverage obtained from a Symbiotic Culture of Bacteria and Yeast (SCOBY), has shown potential in modulating gut microbiota, although no clinical trials have been done.

Objective: We aimed to evaluate the effects of regular black tea kombucha consumption on intestinal health in individuals with and without obesity.

Methods: A pre-post clinical intervention study was conducted lasting eight weeks.

View Article and Find Full Text PDF

Long-term follow-up study of Kudo Type-5 elbow prosthesis in patients with rheumatoid arthritis: minimum 10-year clinical outcomes.

J Shoulder Elbow Surg

December 2024

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. Electronic address:

Objectives: Rheumatoid arthritis often leads to debilitating damage in the elbow joint, which may require total elbow arthroplasty (TEA). The Kudo TEA is one of the unlinked type prostheses with reportedly favorable outcomes. However, there is limited information available regarding its long-term performance.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!