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Glucosinolates and Indole-3-carbinol from L. as inhibitors of CdtB: insights from molecular docking, dynamics, DFT and in vitro assay.
In Silico Pharmacol
October 2024
Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205 Bangladesh.
Unlabelled: (), a common human gut bacterium, is generally harmless but capable of causing infections and contributing to diseases like urinary tract infections, sepsis/meningitis, or diarrheal diseases. Notably, is implicated in developing gallbladder cancer (GBC) either through ascending infection from the gastrointestinal tract or via hematogenous spread. Certain strains are known to produce toxins, such as cytolethal distending toxins (CDTs), that directly contribute to the genetic mutations and cellular abnormalities observed in GBC.
View Article and Find Full Text PDFClinicopathological Findings and Comprehensive Review of Buschke-Lowenstein Tumors Based on a Case Study.
J Pers Med
August 2024
Department 11, Discipline Plastic and Reconstructive Surgery, Bucharest Clinical Emergency Hospital, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania.
Article Synopsis
- The Buschke-Löwenstein tumor (BLT) is a rare, exophytic tumor linked to low-risk HPV strains, primarily appearing as a large, cauliflower-like growth in genital areas, which can be locally aggressive and has a notable recurrence rate.
- A 68-year-old patient with multiple health issues presented with a sizable tumor causing erectile dysfunction and urinary problems, which was successfully surgically excised with reconstruction.
- Histopathological analysis confirmed the diagnosis, and the patient's recovery underscores the importance of early diagnosis and surgical intervention to manage BLT and prevent complications like malignancy and recurrence.
Large cell neuroendocrine carcinoma of the cervix: a case report.
Front Oncol
July 2024
Department of Gynecology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
Large Cell Neuroendocrine Carcinoma (LCNEC) of the cervix is an extremely rare but highly aggressive type of cervical cancer and it requires multimodal therapy to improve their quality of life. At present, there are no established, standardized treatment protocols for managing large cell neuroendocrine carcinoma of the cervix. In this report, we present a case of a patient with cervical LCNEC, Who was a 39-year-old woman who presented with irregular vaginal bleeding accompanied by lower abdominal distension for over a month.
View Article and Find Full Text PDFCase report: A rare case of malacoplakia resembling a malignant tumor of the cervix: a case report and review of the literature.
Front Med (Lausanne)
June 2024
Department of Gynecology, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Article Synopsis
- - Malacoplakia is a rare chronic disease affecting mainly the gastrointestinal and urinary tracts, particularly in immunocompromised patients, and seldom involves the female reproductive tract; a case report details a 56-year-old woman's experience with cervical and vaginal malacoplakia post-thymectomy.
- - The patient had recurrent vaginal bleeding, and colposcopy revealed alterations in the cervical pattern suggestive of cervical cancer, while tissue examination showed macrophage aggregation and specific body formations.
- - Treatment included surgical resection of lesions and antibiotic vaginal lavage, emphasizing a new approach to managing genital malacoplakia in patients with underlying health conditions.
S-Methyl Cysteine Sulfoxide Does Not Ameliorate Weight Gain or Hyperlipidemia in Mice Fed a High-Fat Diet.
Mol Nutr Food Res
May 2024
Nutrition and Health Innovation Research Institute, School of Medical and Health Science, Royal Perth Hospital Research Foundation, Edith Cowan University, Perth, Western Australia, 6000, Australia.
Scope: Higher intake of cruciferous and allium vegetables is associated with lower cardiometabolic risk. Little research has investigated the cardiometabolic effects of S-methyl cysteine sulfoxide (SMCSO), found abundant in these vegetables. This study hypothesizes that SMCSO will blunt development of metabolic syndrome features in mice fed high-fat feed.
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