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Development of cefepime-induced encephalopathy in a patient with depression and rectal cancer: A case report.
Neuropsychopharmacol Rep
March 2025
National Cancer Center Hospital, Tokyo, Japan.
Article Synopsis
- Cefepime, a fourth-generation antibiotic, can cause neurotoxic side effects like encephalopathy, particularly in patients with compromised blood-brain barriers (BBB) and renal issues.
- A case study of a 79-year-old woman with depression and cancer demonstrated that after receiving cefepime, she developed confusion and other neurological symptoms without apparent brain damage or kidney dysfunction.
- The case suggests that depression and cancer may increase the risk of cefepime-induced encephalopathy, highlighting the need for doctors to monitor such patients closely to avoid misdiagnosis and ensure proper treatment.
Clinical, neuropathological, and molecular characteristics of rapidly progressive dementia with Lewy bodies: a distinct clinicopathological entity?
Alzheimers Res Ther
September 2024
Department of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.
Background: The term rapidly progressive dementia (RPD) with Lewy bodies (rpDLB) is used for DLB patients who develop a rapidly progressive neurological syndrome and have reduced survival. Here, we characterise the clinical, neuropathological, and molecular characteristics of a large rpDLB neuropathological series.
Methods: We included all RPD patients with a disease duration < 4 years submitted to our prion disease referral centre between 2003 and 2022 who showed Lewy body pathology (LBP) in limbic or neocortical stages as primary neuropathological diagnosis, had no systemic condition justifying the rapid deterioration and were previously neurologically unimpaired.
Myoclonus, Uremia, and Delirium in a Liver Transplant Recipient: A Case Report and Literature Review.
J Acad Consult Liaison Psychiatry
November 2024
Division of Medical Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA.
Background: Consultation-liaison (CL) psychiatrists are frequently asked to consult on various abnormal movements (1). CL psychiatrists can be instrumental in aiding the primary teams to identify and manage these movement disorders. In this manuscript, we provide an illustrative case of a patient presenting with myoclonus and offer a review on this important topic.
View Article and Find Full Text PDFUsefulness of Gabapentin as an Alternative/Adjunct Therapy for Delirium: A Retrospective Observational Study.
J Nippon Med Sch
May 2024
School of Human Health Sciences, Graduate School of Medicine, Kyoto University.
Background: Antipsychotics are commonly used to treat delirium but can adversely affect the extrapyramidal and cardiac conduction systems. Antipsychotic use has also been reported to be associated with increased mortality in older adults. Therefore, alternative and adjunct medications for delirium are necessary.
View Article and Find Full Text PDFCreutzfeldt-Jakob Disease: A Rare Case of Dementia.
Cureus
October 2023
Internal Medicine, Centro Hospitalar Lisboa Ocidental, Lisbon, PRT.
Prion diseases are rare neurodegenerative diseases that have a rapid evolution. Creutzfeldt-Jakob disease (CJD) is the most common and its sporadic form the most frequent. Definitive diagnosis is only obtained through autopsy, and there are currently no available treatments.
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