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Systematic review and meta-analysis of standalone digital interventions for cognitive symptoms in people without dementia.
NPJ Digit Med
October 2024
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Article Synopsis
- Cognitive symptoms are common in various neuropsychiatric disorders, leading to increased distress and lower quality of life, but self-guided digital interventions could help bridge treatment gaps.
- A meta-analysis of 76 trials involving over 5,200 participants showed that these interventions had a small-to-moderate positive effect on cognitive function and mental health, while their impact on fatigue and quality of life was only marginally significant.
- Though self-guided digital interventions can benefit some patients in the short term, their effectiveness on daily living activities and long-term outcomes is still unclear.
Sequential adaptive trial designs can help accomplish the goals of personalized medicine, optimizing outcomes and avoiding unnecessary toxicity. Here we describe the results of incorporating a promising antibody-drug conjugate, datopotamab-deruxtecan (Dato-DXd) in combination with programmed cell death-ligand 1 inhibitor, durvalumab, as the first sequence of therapy in the I-SPY2.2 phase 2 neoadjuvant sequential multiple assignment randomization trial for high-risk stage 2/3 breast cancer.
View Article and Find Full Text PDFAmong the goals of patient-centric care are the advancement of effective personalized treatment, while minimizing toxicity. The phase 2 I-SPY2.2 trial uses a neoadjuvant sequential therapy approach in breast cancer to further these goals, testing promising new agents while optimizing individual outcomes.
View Article and Find Full Text PDFConsumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial.
Nat Med
July 2024
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
Article Synopsis
- The RATE-AF trial investigated the impact of two heart medications, digoxin and beta-blockers, on heart rate in older patients with atrial fibrillation and heart failure, using consumer-grade wearable technology.
- Over 20 weeks, heart rate data from 53 participants showed no significant difference between the two treatment groups, regardless of physical activity levels.
- The study suggests that wearables could effectively monitor patients' heart health remotely, providing comparable predictive insights to traditional clinical assessments.
Ketamine reduces the neural distinction between self- and other-produced affective touch: a randomized double-blind placebo-controlled study.
Neuropsychopharmacology
October 2024
Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
A coherent sense of self is crucial for social functioning and mental health. The N-methyl-D-aspartate antagonist ketamine induces short-term dissociative experiences and has therefore been used to model an altered state of self-perception. This randomized double-blind placebo-controlled cross-over study investigated the mechanisms for ketamine's effects on the bodily sense of self in the context of affective touch.
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