Background: The aim of this study was to evaluate the compaction behavior of a model two-component amorphous spray-dried dispersion system compared with the unprocessed excipients, using simulated rotary tablet press production conditions.
Method: In this study, the stabilizing polymer, hypromellose acetate succinate (HPMCAS), was solubilized and spray dried with and without sodium lauryl sulfate (SLS). The impact of compression force and speed on the tabletting process was quantified by means of tablet tensile strength, compaction energy, and Heckel analysis.
Results: Addition of the surfactant SLS, spray dried or as a physical mix, reduced the tablet strength. However, a lesser impact on the unprocessed excipients was observed in comparison with the spray-dried excipients. In the presence of 1% (w/w) SLS, tablets displayed a tendency to cap when compressed at higher speeds, supported by high elastic energy values indicating high uniaxial stress upon decompression. In the presence of 3% (w/w) SLS, tablets could not be produced at high speeds. Heckel analysis revealed a greater strain rate sensitivity of HPMCAS when spray dried in the presence of surfactant. Exposure of samples to a range of relative humidities before compaction had no effect on tablet strength.
Conclusion: This study has shown that spray drying of HPMCAS in the presence of a surfactant affects the compressibility of the material, resulting in decreased tablet strength, increased elastic deformation, and capping.
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http://dx.doi.org/10.3109/03639045.2010.509349 | DOI Listing |
ADMET DMPK
October 2024
Siberian Federal University, 79 Svobodny pr., Krasnoyarsk 660041, Russia.
Background And Purpose: Cyclophosphamide (CP) is a widely used antitumor and immunosuppressive drug, but it is highly cytotoxic and has carcinogenic and teratogenic potential. To reduce adverse effects of CP therapy and the frequency of its administration, the microencapsulation of CP into biodegradable polymeric matrices can be performed. However, according to the literature, only a few polymers were found suitable to encapsulate CP and achieve its' sustained release.
View Article and Find Full Text PDFACS Bio Med Chem Au
December 2024
The University of Arizona College of Pharmacy, Skaggs Pharmaceutical Sciences Center, Tucson, Arizona 85721, United States.
This study introduces novel cospray-dried (Co-SD) formulations of simvastatin, a Nrf2 activator ROCK inhibitor, with l-carnitine as molecular mixtures in various molar ratios for targeted pulmonary inhalation aerosol delivery in pulmonary hypertension, optimized for excipient-free dry powder inhalers (DPIs). The two components were spray-dried at various molar ratios by using different starting feed solution concentrations and process parameters. In addition to comprehensive physicochemical characterization, in vitro aerosol dispersion performance as DPIs using two FDA-approved DPI devices with different shear stress properties, in vitro viability as a function of dose on 2D human pulmonary cellular monolayers and on 3D small airway epithelia human primary cultures at the air-liquid interface (ALI), and in vitro transepithelial electrical resistance (TEER) at the ALI were conducted.
View Article and Find Full Text PDFFood Chem
December 2024
Institute for Egg Science and Technology, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, China. Electronic address:
Egg white protein's functional properties and digestibility can be significantly affected by processing methods. In this study, a novel combined ultrasound-heating (UH) pretreatment protocol was developed, where liquid egg white was subjected to ultrasonic treatment (0.4 W/mL, 10 min) followed by mild heating (72 °C, 10 min) prior to drying processes.
View Article and Find Full Text PDFFood Chem
December 2024
Laboratory of Applied Food Chemistry, Microbiology and Process Engineering, Centre for Food Engineering and Technology, Department of Chemical Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India. Electronic address:
This study presents a novel gelatinization-induced whole-grain rice fortification (GIWGRF) technology using a microwave-assisted screw conveying spraying and drying setup (MASCSD). The process involves microwave-assisted soaking of pregelatinized rice in a micronutrient solution, followed by steam-assisted gelatinization and drying. Rice with an initial degree of gelatinization (DG) of 58.
View Article and Find Full Text PDFTransl Anim Sci
December 2024
Institute of Animal Science, Beef Cattle Research Center, Sertãozinho, Brazil.
The objective of this study was to evaluate the efficacy of using 3 yeast-based additives as an alternative to sodium monensin on rumen fermentation parameters using a dual-flow continuous fermentation system. Ten fermenters (1,223 ± 21 mL) were used in 2 simultaneous 5 × 5 Latin squares arrangement with 3 periods of 10 d each, with 7 d for diet adaptation and 3 d for sample collections. Each Latin square assigning either a low or high level of concentrate to beef cattle diets, with 5 specified treatments: Control: no additives; Blend 1: yeast culture (), beta-glucans, fructooligosaccharides, galactooligosaccharides, and mannanoligosaccharides [1,600 mg/kg dry matter (DM)]; Blend 2: Beta-glucan and mannanoligosaccharide fractions from (1,600 mg/kg DM); Yeast Cells: hydrolyzed, inactivated, and spray-dried yeast cells (; 2,133 mg/kg DM); monensin (25 mg/kg DM).
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