AI Article Synopsis
- Several N,O-nucleosides were successfully created using a method called direct 1,3-dipolar cyclization without any solvent, yielding good results.
- A high level of cis stereoselectivity (over 98%) was achieved by adjusting the side groups on the nitrone part of the molecules.
- Many of these N,O-nucleosides have been tested for their ability to kill cells, with some showing promise as potential new drugs to inhibit cell growth.
Article Abstract
Several N,O-nucleosides have been synthesized in good yields by direct 1,3-dipolar cyclization methodology, in the absence of solvent. A remarkable cis stereoselectivity (de 98%) was observed by tuning the substituents on the nitrone moiety. A good number of these N,O-nucleosides have been evaluated for cytotoxic activity against selected cellular lines. Some of the tested compounds have proven to be potential antiproliferative drugs.
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| http://dx.doi.org/10.1016/j.bmc.2010.08.024 | DOI Listing |
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